Influence of thyroid gland in women with abnormal uterine bleeding in reproductive age group

Authors

  • Kavitha Marimuthu Department of Obstetrics and Gynecology, Government Dharmapuri Medical College Hospital, Dharmapuri, Tamil Nadu, India
  • Malarvizhi Loganathan Department of Obstetrics and Gynecology, Government Dharmapuri Medical College Hospital, Dharmapuri, Tamil Nadu, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20172027

Keywords:

Abnormal uterine bleeding, Free T3, Free T4, Hypothyroidism, Thyrotoxicosis, TSH

Abstract

Background: Abnormal Uterine Bleeding is a common complaint encountered in Gynaecology OPD. It occurs in 9-14% of women from Menarche to Menopause affecting quality of life imposing financial burden. Thyroid dysfunction causes broad spectrum of reproductive disorders from abnormal sexual development, menstrual irregularities, infertility and premature menopause. Thyroid disorders are 10 times more common in women and increased prevalence of thyroid disorders in women is possibly due to auto immune nature.

Methods: This Prospective study population consisted of 250 women attending the Gynaecology Outpatient Clinic, in Government Dharmapuri Medical College Hospital, with complaints of bleeding problems during menstruation in the age group of 18 to 45 years.

Results: Of 250 cases of abnormal uterine bleeding in reproductive age group attending the outpatient department about 68 cases have thyroid dysfunction. The common thyroid dysfunction in our study was hypothyroidism which comprises about 15.6% similarly other thyroid dysfunction are hyperthyroidism in 7.2% and subclinical hypothyroidism in 3.2% and subclinical hyperthyroidism 1.2%.

Conclusions: It brings into focus the increased incidence of hypothyroidism among women with menorrhagia and amenorrhea. And increased incidence of hyperthyroidism in women with oligomenorrhea. Early detection by selective screening and specific pharmacotherapy for subclinical thyroid disease early in the course of the disease will prove to be a superior alternative to surgical treatments like hysterectomy.

References

Fraser IS, Langham S, Uhl-Hochgraeber K. Health-related quality of life and economic burden of abnormal uterine bleeding. Expert Rev Obstet Gynaecol. 2009;4(2):179-89.

Thomas R, Reid RL. Thyroid diseases and reproductive dysfunction. Obstet Gynaecol 1987;70:789-98.

Mazzaferri EL. Evaluation and management of common thyroid disorders in women. Am J Obstet Gynaecol. 1997;176(3):144-9.

Sruthi M, Amruthlal W, Reddy GC, Kusumanjali G, Kanagasabapathy AS, Pragna R. diagnostic strategies for subclinical hypothyroidism. Indian J Clini Biochem. 2008;23(3):279-82.

Petta CA. Thyroid screening in menstrual abnormalities. N Eng J Med. 2007;76:463-70.

Vanderpump MP, Tunbrldge WM, French J, Appleton D, Bates D, Clark F et al. The incidence of thyroid disorders in the community: a twenty five year follow up of whickam survey. Clin Endocrinol (Oxf). 1995;43(1):55-68.

Sampath S, Singh P, Somani BL, Arora MM, Batra HS, Harith AK et al. Study of clinicobiochemical spectrum of hypothyroidism. MJAFI. 2007;63(3):233-6.

Weeks AD. Correlating menstrual irregularities with levels of thyroid hormone deficiency. BMJ 2000;320(7235):649.

Singh P. Pattern of bleeding in hypothyroidism. MJAFI. 2007;53:112-23.

Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA. Serum T4 and TSH in the united states population (1988-1994): national health and nutrition examination survey (NHANES III). J Clin Endocrinol Metab. 2002;87(2):489-99.

Downloads

Published

2017-05-25

Issue

Section

Original Research Articles