Combination of mifepristone and misoprostol: an effective method of medical abortion upto gestational age of 49 days

Seema C. Kshirsagar Kshirsagar; Uma Nitin Wankhede

doi:10.18203/2320-1770.ijrcog20172908

Authors

Seema C. Kshirsagar Kshirsagar Department of Obstetrics and Gynecology, B.J.G.M.C. and S.G.H., Pune, Maharashtra, India
Uma Nitin Wankhede Department of Obstetrics and Gynecology, B.J.G.M.C. and S.G.H., Pune, Maharashtra, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20172908

Keywords:

Abortion, Medical, Mifepristone, Misoprostol

Abstract

Background: A combination of antiprogesterone mifepristone and prostaglandin analogue misoprostol provides an effective non surgical method for termination of pregnancy up to gestational age of 49 days. Objective of present study was to assess the efficacy of this medical regimen for termination of pregnancy up to 49 days of pregnancy.

Methods: A hospital based retrospective study was carried out in Department of Obstetrics and Gynecology in Sassoon General Hospital, Pune, India for a period of one year where 30 women requesting for medical abortion were studied. The medical regimen used was mifepristone 200 mg orally followed 48 hours later by misoprostol 800 microgram administered in posterior vaginal fornix.

Results: The overall success rate of this regimen was 90%. Where success was defined as achieving complete abortion without needing surgical evacuation. Surgical evacuation was needed in 3 (10%) patients i.e. for incomplete abortion.

Conclusions: Combination of oral mifepristone 200mg followed 48 hours later by vaginal misoprostol 800mcg is an effective method of medical termination of pregnancy.

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References

Ulmann A, Silvestre L, Chemama L, Rezvani Y, Renault M, Aguillaume CJ et al. Medical termination of early pregnancy with mifepristone (RU 486) followed by a prostaglandin analogue. Study in 16,369 women. Acta Obstet Gynecol Scand. 1992;71(4):278-83.

Kulier R, Kapp N, Gülmezoglu AM, Hofmeyr GJ, Cheng L, Campana A. Medical methods for first trimester abortion. The Cochrane Library. 2004;11:CD002855.

Creinin MD, Danielsson, Gemzell K. Medical abortion in early pregnancy. In Maureen P, Lichtenberg M, Steve E, Lynn B, David A. Phillip G et al. Management of unintended and abnormal pregnancy : comprehensive abortion care. Oxford: Wiley-Blackwell; 2009:111-134.

Jones RK, Jerman J. Abortion incidence and service availability in the United States, 2011. Perspect Sex Reprod Health. 2014;46(1):3-14.

Pymar HC, Creinin MD. Alternatives to mifepristone regimens for medical abortion. Am J Obstet Gynecol. 2000;183(2 Suppl):S54-64.

Creinin MD. American College of Obstetricians and Gynecologists. Medical management of abortion. Practice Bulletin. 2001;26:1-13.

Paul M, Lichtenberg ES, Borgatta L, Grimes DA, Stubblefield PG et al. A Clinician’s Guide to Medical and Surgical Abortion. New York: Churchill Livingstone; 1999.

Rowan A. Prosecuting women for self-inducing abortion: counterproductive and lacking compassion. Guttmacher Policy Review. 2015;18(3):70-6.

Goldberg AB, Greenberg MB, Darney PD. Misoprostol and pregnancy. N Engl J Med. 2001;344(1):38-47.

WHO Department of Reproductive Health and Research. Safe abortion: technical and policy guidance for health systems 2nd ed. Geneva: World Health Organization. 2012;46:1-9.

Godara S, Kaushal J. Practice of self-medication of mifepristone-misoprostol drug combination for medical abortion. Int J Basic Clin Pharmacol. 2014;3(3):572-3.