Combination of mifepristone and misoprostol: an effective method of medical abortion upto gestational age of 49 days

Seema C. Kshirsagar Kshirsagar, Uma Nitin Wankhede


Background: A combination of antiprogesterone mifepristone and prostaglandin analogue misoprostol provides an effective non surgical method for termination of pregnancy up to gestational age of 49 days. Objective of present study was to assess the efficacy of this medical regimen for termination of pregnancy up to 49 days of pregnancy.

Methods: A hospital based retrospective study was carried out in Department of Obstetrics and Gynecology in Sassoon General Hospital, Pune, India for a period of one year where 30 women requesting for medical abortion were studied. The medical regimen used was mifepristone 200 mg orally followed 48 hours later by misoprostol 800 microgram administered in posterior vaginal fornix.

Results: The overall success rate of this regimen was 90%. Where success was defined as achieving complete abortion without needing surgical evacuation. Surgical evacuation was needed in 3 (10%) patients i.e. for incomplete abortion.

Conclusions: Combination of oral mifepristone 200mg followed 48 hours later by vaginal misoprostol 800mcg is an effective method of medical termination of pregnancy.


Abortion, Medical, Mifepristone, Misoprostol

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