DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20163828

Obstetric and neonatal outcomes among pregnancies with hepatitis E infection

Sachin Hiralal Pardeshi, Niranjan Mayadeo

Abstract


Background: Maternal mortality is an important health indicator. Hepatitis E is a common viral infection affecting pregnant women. The maternal morbidity and mortality relating to this infection is not extensively reported and deserves to be studied.

Methods: A retrospective study was conducted in a tertiary care referral centre and the obstetric and neonatal outcomes among patients with hepatitis E infection were studied for duration of 1 year.

Results: Among 24 patients, there were 7 mortalities. Majorities were primigravidae and presented during third trimester. A sizeable number required blood transfusions and ICU stay. 7 were stillbirths and majorities were low birth weight babies.

Conclusions: Hepatitis E causes significant maternal and neonatal morbidity.


Keywords


DIC, Hepatitis E, Jaundice, Maternal mortality, Viral hepatitis

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References


Dienstag JL. Acute Viral Hepatitis In: Longo LD, Kasper DL, Jameson JL, Fauci AS, Hauser SL, Loscalzo J. eds. Harrison’s Principles of Internal Medicine. New York. 18th edn. McGraw Hill; 2014.

Kumar T, Shrivastava A, Kumar A, Laserson KF, Narain JP, Venkatesh S. Viral Hepatitis Surveillance--India, 2011-2013. MMWR Morb Mortal Wkly Rep. 2015;64(28):758-62.

Singla A, Mehta S, Rajaram S, Shree S. Materno-Fetal Outcomes with Viral Hepatitis in Pregnancy. J Obst Gyn India. 2016;66(3):166-9.

Shinde N, Patil T, Deshpande A, Gulhane R, Patil M, Bansod Y. Clinical profile, maternal and fetal outcomes of acute hepatitis E in pregnancy. Ann Med Health Sci Res. 2014;4(2):S133-9.

Begum N, Devi SG, Husain SA, Kumar A, Kar P. Seroprevalence of subclinical HEV infection in pregnant women from north India: a hospital based study. Indian J Med Res. 2009;130(6):709-13.

Sultana R, Humayun S. Fetomaternal outcome in acute hepatitis e. J Coll Physicians Surg Pak. 2014;24(2):127-30.

El Sayed Zaki M, El Razek MMA, El Razek HMA. Maternal-Fetal hepatitis E Transmission: Is It Underestimated? J Clin Transl Hepatol. 2014;2(2):117-23.

Jin H, Zhao Y, Zhang X, Wang B, Liu P. Case-fatality risk of pregnant women with acute viral hepatitis type E: a systematic review and meta-analysis. Epidemiol Infect. 2016;144(10):2098-106.

Khaskheli MN, Baloch S, Sheeba A, Baloch S. Acute hepatitis E Viral Infection in Pregnancy and Maternal Morbidity. J Coll Physicians Surg Pak. 2015;25(10):734-7.