Can Co-enzyme Q10 improve the chances of conception after the age of 35?


  • Eman Ali Abd El Fattah Department of Obstetrics and Gynecology, Alexandria University, Shatby Maternaty Hospital, Alexandria, Egypt



Co- enzyme Q10, Ovarian reserve, Pregnancy


Background: ovarian follicular quality diminishes with age, Free radicals and oxidative stress begin to accumulate in cells, aging or slowing down the metabolic energy production centers in the cell- the mitochondria. When the mitochondria cannot generate a certain amount of energy, it slows growth and proper development of the follicle making it more prone to DNA damage, including chromosomal abnormalities resulting in poor fertilization patterns, and early miscarriage. Co-enzyme Q10 (CoQ10) is a major cellular antioxidant. its tissue levels gradually decrease with age. We attempt to evaluate its protective effect on ROS-induced ovarian damage, which is one of the most important and widely accepted patho- mechanisms underlying cell ageing.

Methods: 40 Participants   from El Shatby hospital infertility clinic 35 to 38 years old, with history of bad response to ovulation stimulation, were divided into two equal groups (group A given (CoQ10) 3mg|kg body weight for three cycles prior to stimulation Serum anti- mullarian hormone level was measured before and after CoQ10 administration, group B= twenty cases as control). Participants were given gonadotrophins (150 IU to 375 IU). Follicular growth was monitored by trans- vaginal ultra- sonography and serum estradiol level (E2). Ovulation trigger was achieved using 10,000 IU of human chorionic gonadotrophin.

Results: The primary outcome was occurrence of normal pregnancy; secondary outcome was good response to stimulation (at least one mature follicle 18-22mm).

Conclusions: CoQ10 has no significant effect on response to ovulation stimulation or on pregnancy rates.


Titus S, Li F, Stobezki R, Akula K, Unsal E, Jeong K et al. Impairment of BRCA1-related DNA double-strand break repair leads to ovarian aging in mice and humans. Sci Transl Med. 2013;5(172):172.

Dumollard R, Ward Z, Carroll J, Duchen MR. Regulation of redox metabolism in the mouse oocyte and embryo. Development. 2007;134:455-65.

Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol. 1956;11(3):298-30.

Meldrum DR. Aging gonads, glands, and gametes: immutable or partially reversible changes? Fertil Steril. 2013;99(1):1-4.

Li Q, Geng X, Zheng W, Tang J, Xu B, Shi Q. Current understanding of ovarian aging. Sci China Life Sci. 2012;55(8):659-69.

Bentov Y, Casper RF. The aging oocyte-can mitochondrial function be improved? Fertil Steril. 2013;99(1):18-22.

Santos-Ocana C, Do TQ, Padilla S, Navas P, Clarke CF. Uptake of exogenous coenzyme Q and transport to mitochondria is required for bc1 complex stability in yeast coq mutants. J Biol Chem. 2002;277(13):10973-81.

Villalba JM, Navas P. Plasma membrane redox system in the control of stress-induced apoptosis. Antioxid Redox Signal. 2000;2000(2):213-30.

Pignatti C, Cocchi M, Weiss H. Coenzyme Q10 levels in rat heart of different age. Biochem Exp Biol. 1980;16(1):39-42.

IBM Corp. Released 2012. IBM SPSS Statistics for Windows, Version 21.0. Armonk, NY: IBM Corp.

Field A, ed. Discovering Statistics Using SPSS. 2nd ed. London, California, New Delhi:SAGE Publications Ltd;2006.

Welch BL. The generalization of Students’ problem when several different population variances are involved. Biometrika. 1947;34(1-2):28-35.

Ruxton GD. The unequal variance t-test is an underused alternative to Student's t-test and the Mann-Whitney U test. Behav Ecol. 2006;17:688-90.

Mann HB, Whitney DR. On a Test of Whether one of two random variables is stochastically larger than the other. Annals Mathemat Statist. 1947;18(1):50-60.

Bentov Y, Hannam T, Jurisicova A, Esfandiari N, Casper RF. Coenzyme Q10 supplementation and oocyte Aneuploidy in women undergoing IVF-ICSI treatment. Clin Med Insights Reprod Health. 2014;8:31-6.

Refaeey EA, Selem A, Badawy A. Combined coenzyme Q10 and clomiphene citrate for ovulation induction in clomiphene-citrate-resistant polycystic ovary syndrome. Reprod Biomed Online. 2014;29(1):119-24.






Original Research Articles