Clinico pathological study of ovarian neoplasms
Keywords:Benign, Ovarian neoplasm, Oophorectomy
Background: Ovarian tumors are common form of neoplasm in women and account for 30% of female genital tract cancers. Ovarian cancer is the sixth most common cancer in women and the leading cause of death in women with gynaecological malignancy. Due to inefficient diagnosis/prognosis strategies mainly due to the lack of specific symptoms at the initial stage of the disease about 70% cases diagnose at advanced stage when the metastatic tumor has acquired drug resistant phenotype.
Methods: Prospective study of two years duration with sample of 108 cases of simple oophorectomy and hysterectomy with unilateral or bilateral salpingo oophorectomy specimens are included in this study.
Results: Maximum cases were in the age group of 21 to 45 years. Mean age of presentation was 42.84 years (benign tumors), 46.66years (Borderline tumors) and 32.6 years (malignant tumors). Epithelial ovarian tumors are the commonest and constituted 78.7% of all ovarian tumors. In present study 40.74% were benign, 2.78% were borderline and 56.48% were malignant ovarian tumors.
Conclusions: Most of the ovarian neoplasms presented in the reproductive age group but ovarian malignancy can occur at all age group and abdominal symptoms are the only clue for the diagnosis of the disease. There is no definite universal screening protocol yet, for malignant ovarian tumors however abdominal symptoms supported by tumor markers like serum CA-125 and ultrasound of abdomen and pelvis with Doppler may be yardstick for early diagnosis of malignant ovarian tumor.
Swamy GG, Satyanarayana N. Clinicopathological analysis of ovarian tumors: A study on five years samples. Nepal Med Coll J. 2010;12(4):221-3.
Kuladeepa AVK, Muddegowda PH, Lingegowda JB, Doddikoppad MM, Basavaraja PK, Hiremath SS. Histomorphological study of 134 primary ovarian tumors. Adv Lab Med Int. 2011;1(4):69-82.
Paes MF, Daltoé RD, Madeira KP, Rezende LC, Sirtoli GM, Herlinger AL et al. A retrospective analysis of clinicpathological and prognostic characteristics of ovarian tumors in the state of Espirito Santo, Brazil. J Ovarian Res. 2011;4:14.
Scully RE, Young RH, clement PB. In: atlas of tumor pathology: tumor of the ovary, maldeveloped gonads, fallopian tube nad broad ligament, 3rd ed. Washington;1998:27.
Malhotra N, Kumar P, Malhotra J, Boro NM, Mittal P. Jeffcoate’s Principles of Gynaecology; 8th Ed Jaypee Brothers Medical Publishers (P) Ltd;2014.
Padubidri VG, Daftary S. Howkins and Bourne shaw’s Textvook of Gynecology. 15 th ed. Elsevier India;2010.
Sharadha SO, Sridevi TA, Renukadevi TK, Gowri R, Binayak D, Indra V. Ovarian masses: changing clinico histopathological trends. J Obstet Gynaecol India. 2015;65(1):34-38.
Breen JL, Denehy TR, Taylor RR. Pediatric ovarian malignancies. Sarcoma. 2008;3:0-3.
Levy G, Purecell K. Current Diagnosis and Treatment Obstetrics and Gynecology. 11th Ed. 2013:848-58.
Garg R, Singh S, Rani R, Agarwal M, Rajbansi R. A clinicopathological study of malignant ovarian tumors in India. J South Asian Feder Menopause Soc. 2014;2(1):9-11.