Uterine myxoid leiomyosarcoma: a diagnostic challenge

Jayalakshmi Durairaj, Swaramya Chandrasekaran


Uterine sarcomas are histologically diverse tumours which comprise about 3-7% of uterine malignancies. Myxoid leiomyosarcoma (MLMS) is an extremely uncommon variant of uterine leiomyosarcoma. This report is of a 35 year old woman who presented with urinary retention and abnormal vaginal bleeding, who underwent a total abdominal hysterectomy for cervical fibroid. A diagnosis of leiomyoma with myxomatous degeneration was made. The woman subsequently developed a recurrence within 5 months of the surgery and was diagnosed with MLMS following biopsy. This case reiterates the uncertainties associated with the diagnosis of MLMS and the need for heightened vigilance in women with myxomatous degeneration of leiomyoma.


Myxomatous degeneration, Uterine myxoid leiomyosarcoma, Uterine sarcomas

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Major FJ, Blessing JA, Silverberg SG, Morrow CP, Creasman WT, Currie JL et al. Prognostic factors in early-stage uterine sarcoma: A gynecologic oncology group study. Cancer. 1993;71(S4):1702-9.

World Health Organization classification of tumours. In: Tavassoli FA, Devilee P, editors. Pathology and genetics of tumours of the breast and female genital organs. Lyon: IARC Press; 2003.

Uterine-Sarcomas-review. Available at

Gadducci A, Landoni F, Sartori E, Zola P, Maggino T, Lissoni A, et al. Uterine leiomyosarcoma: analysis of treatment failures and survival. Gynecol Oncol. 1996;62(1):25-32.

Leanza V, Marilli I, Genovese F, Leanza G. Uterine Myxoid Leiomyosarcoma Associated with Multiple Myomas in a Fertile Woman: A Case Report. Gynecol Obstet. 2012;2(128):2161-0932.