Maternal factors associated with large for gestational age babies and its outcome when compared with those of appropriate for gestational age


  • Lopamudra B. John Department of Obstetrics and Gynecology, Mahatma Gandhi Medical College and Research Institute, Pondicherry, India
  • Reddi Rani P. Department of Obstetrics and Gynecology, Mahatma Gandhi Medical College and Research Institute, Pondicherry, India
  • Seetesh Ghose Department of Obstetrics and Gynecology, Mahatma Gandhi Medical College and Research Institute, Pondicherry, India



Large for gestational age, Maternal factors, Outcome


Background: Large for gestational age (LGA) babies are known to have a higher incidence of birth trauma, difficult delivery and Caesarean sections. Knowledge about maternal factors associated with this can help in prediction and prevention of complications.

Methods: Maternal factors in 112 cases of LGA babies was studied along with its outcome and compared with an equal number of controls.

Results: 0.05% deliveries resulted in LGA babies. Age and parity were not significantly different in the two groups and so were the associated medical disorders of hypothyroidism and gestational hypertension. Significant association was found with post-dated pregnancies (p=0.04) and gestational diabetes mellitus (p=0.05). Also, higher number of primary Caesarean sections resulted in the case group.

Conclusions: Post dated pregnancies and gestational diabetes were maternal factors associated with LGA babies and higher number of primary Caesarean sections resulted in these cases.


Orskou J, Kesmodel U, Henriksen TB. An increasing proportion of infants weigh more than 4000 grams at birth. Acta Obstet Gynecol Scand 2001;80:931-6.

Walsh JM, McAuliffe FM. Prediction and prevention of the macrosomic fetus. Eur J Obstet Gynecol Reprod Biol. 2012;162:125-30.

Boulet SL, Alexander GR, Salihu HM, Pass M. Macrosomic births in the united states: determinants, outcomes, and proposed grades of risk. Am J Obstet Gynecol. 2003;188(5):137-8.

Weissmann-Brenner A, Simchen MJ, Zilberberg E. Maternal and neonatal outcomes of large for gestational age pregnancies. Acta Obstet Gynecol Scand 2012;91:844-9.

Khalil A, Syngelaki A, Maiz N, ZInevich y, Nicolaides KH. Maternal age and adverse pregnancy outcomes-a cohort study. Ultrasound Obstet Gynecol. 2013;42(6):634-43.

Lan-Pidhainy X, Nohr EA, Rasmussen KM. Comparison of gestational weight gain –related pregnancy outcomes in American primiparous and multiparous women. Am J Clin Nutr. 2013; 97(5):1100-6.

Djelantik AA, Kunst AE, van der Wal MF, Smit HA, Vrigkotte TG. Contribution of overweight and obesity to the occurrence of adverse pregnancy outcomes in a multi-ethnic cohort: population attributive factors for Amsterdam. BJOG. 2012;119 (3):283-90.

Chung JG, Taylor RS, Thompson JM, Anderson NH, Dekker GA, Kenny LC. Gestational weight gain and adverse pregnancy outcomes in a nulliparous cohort. Eur J Obstet Gynecol Reprod Biol. 2013; 167(2):149-53.

MacInnis N, Woolcott CJ, Mc Donald S, Kuhle S. Population attributable risk fractions of maternal overweight and obesity for adverse perinatal outcomes. Sci Rep. 2016;10(6):22895.

Averett SL, Fletcher EK. Prepregnancy obesity and birth outcomes. Matern Child Health J. 2016; 20(3):655-64.

Brankica K, Valentina VN, Slagjana SK, Sasha JM. Maternal 75-g OGTT glucose levels as predictive factors for large-for-gestational age newborns in women with gestational diabetes mellitus. Arch Endocrinol Metab. 2016;60(1):36-41.

Almarzouki AA. Maternal and neonatal outcome of controlled gestational diabetes mellitus versus igh risk group without gestational diabetes mellitus: a comparative study. Med Glas (Zenica). 2013;10 (1):70-4.

Kumru P, Erdogdu E, Arisoy R, Demirci O, Ozkoral A, Ardic C. Effect of thyroid dysfunction and autoimmunity and pregnancy outcomes in low risk population. Arch Gynecol Obstet. 2015;291(5):1047-54.

Nazarpour S, Ramezani Teherani F, Simbar M, Azizi F. Thyroid dysfunctions and pregnancy outcomes. Iran J Reprod Med. 2015;13(7):387-96.

Persson M, Pasupathy D, Hanson U, Norman M. Disproportionate body composition and perinatal outcome in large-for-gestational-age infants to mothers with type 1 diabetes. BJOG. 2012;119(5):565-72.






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