DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20173499

Correlation of raised serum uric acid in first trimester of pregnancy and the risk of gestational diabetes: a prospective study

Jayanthi Mohan, Janani Suriyamoorthi, Maya Menon

Abstract


Background: Prevalence of Gestational Diabetes Mellitus (GDM) is fast increasing in India. The association between serum uric acid levels and GDM is not well known. This study was conducted to assess the relationship between first trimester serum uric acid levels and the incidence of gestational diabetes.

Methods: This prospective observational study included 85 antenatal women. Serum uric acid level and oral glucose challenge test (OGCT) were done in all three trimesters. Women with first trimester serum uric acid levels of <3.6 mg were classified as group A and >3.6 mg as group B. Both the groups were followed throughout the pregnancy to assess the development of gestational diabetes. Also, the mode of delivery, pregnancy outcome, and other maternal and neonatal complications were observed.

Results: In the patients recruited into this study, 33.33% of group A (serum uric acid<3.6 mg/dl) and 17.5% of group B (serum uric acid>3.6 mg/dl) developed GDM.

Conclusions: First trimester Serum Uric acid was not significantly related to development of GDM in the sampled women. Neither was it related to any adverse maternal or fetal outcomes.


Keywords


First trimester, Gestational diabetes, Serum uric acid

Full Text:

PDF

References


Baliga P, Thunga S. Uric acid levels in early pregnancy as a predictor of preeclampsia and gestational diabetes mellitus. Internat J Recent Scient Res. 2015;6(6):4611-5.

Güngör ES, Danisman N, Mollamahmutoglu L, Relationship between serum uric acid, creatinine, albumin and gestational diabetes mellitus. Clin Chem Lab Med. 2006;44:974-77.

Javadian P, Alimohamadi S, Gharedaghi MH, Hantoushzadeh S. Gestational diabetes mellitus and iron supplement; effects on pregnancy outcome. Acta Medica Iranica. 2014;52(5):385.

Singh YR, Soni N, Kaushik GG, Sharma S, Broca JS. Study of serum levels of Homocysteine, Vitamin B12 and Folic acid in women with aprevious history of Gestational Diabetes Mellitus. SSRG Int J Med Sci (SSRG-IJMS). 2016;3(3).

Laughon SK, Catov J, Provins T, Roberts JM, Gandley RE. Elevated first-trimester uric acid concentrations are associated with the development of gestational diabetes. Am J Obstet Gynecol. 2009;201(4):402:e1-5.

Kappaganthu A, Sachan J, Shailaja G. Hyperuricemia in early pregnancy a marker for gestational diabetes mellitus. IOSR J Dental Med Sci. 2014;12:51-54.

Rajakumar SA, Thirumal R, Usha V, Rontgen R. Co-Relation between First Trimester Uric Acid Concentration and Development of Gestational Diabetes Mellitus. J Evol Med Dental Sci. 2014;3(02):266-271.

Zhou J, Zhao X, Wang Z, Hu Y. Combination of lipids and uric acid in mid-second trimester can be used to predict adverse pregnancy outcomes. The J Maternal-Fetal Neonat Medic. 2012;25(12):2633-8.