DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20173194

Role of FRIOS (free radical induced oxidative stress) in outcome of pregnancy induced hypertension cases

Anjana Choudhary, Nidhi Tripathi

Abstract


Background: The anti-oxidant and the per oxidation product levels both are increased in pregnancy. Much recent works has focused on the role of oxidative disturbance in the preeclampsia and eclampsia. Preeclampsia remains a leading cause of maternal and fetal morbidity and mortality.

Methods: This prospective study was conducted in upper India sugar exchange and maternity hospital, department of Obstetrics and Gynecology, GSVM Medical College, Kanpur in Collaboration with department of pathology, GSVM Medical College, Kanpur (UP), India. All the patients selected for the present study, both from control and study group was in detail with regard the clinical history, general examination, local examination, basic investigation and Specific Investigation, Super Oxide Dismutase (SOD). Blood samples would be collected with the informed consent from control as well as study group for assessment of antioxidant status by determining levels of superoxide dismutase.

Results: The mean age and BMI of control as well as study group is almost same. The incidence of pre-eclampsia and eclampsia in primipara was 29.31 and in multiparous it was 9.52 in all groups. It implies that 95% cases will have improvement in SOD value with mean difference in improvement of at least 0.297807. There is statistically significant difference in mode of delivery by LSCS in study group A as compared to study group B and control in PIH patients. The incidence of complications is significantly higher in Study Group A as compared to control group and Study Group B. There is statistically significant difference in the incidence of preterm birth in study group A as well as Study Group B as compared to control. However, there was no statistically significant difference in the incidence of preterm birth after giving intervention to the study group. When cut off value of SOD enzyme as < 0.578U/mg of protein, sensitivity is 66.07% and specificity as 51.85%.

Conclusions: Vitamin-c supplementation will only prevent PIT in PIH with already reduced antioxidant status.


Keywords


Oxidative stress, Preeclampsia, Superoxide dismutase

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