Case of extranodal non-hodgkins lymphoma involving the endometrium and the ovaries: a rare case report


  • Lakshmi Manjeera Malempati Department of Obstetrics and Gynecology, K. S. Hegde Medical College, NITTE University, Mangalore, Karnataka, India
  • Neetha Nandan Department of Obstetrics and Gynecology, K. S. Hegde Medical College, NITTE University, Mangalore, Karnataka, India
  • Sagarika Babu Department of Obstetrics and Gynecology, K. S. Hegde Medical College, NITTE University, Mangalore, Karnataka, India



Diffuse large B cell lymphoma, Extra nodal lymphoma, Female genital tract, R-CHOP, Non-Hodgkin’s lymphoma


Non-Hodgkin’s lymphoma(NHL) is most commonly encountered during childhood and rarely among the adults. Primary malignant lymphoma in the female genital tract are rare Moreover they present with non-specific symptoms and hence there may be delay in the diagnosis. It is difficult to distinguish this condition from the more common uterine neoplasm such as uterine fibroids or sarcoma. Diffuse large B-cell lymphoma (DLBCL) is most commonly seen among the cases of NHL, contributing to among one third of NHL in the western world. DLBCL is common in elderly population. A 69-year-old postmenopausal woman who came with watery discharge since, 15 days was evaluated clinically and radiologically and was found to have thickened endometrium and enlarged ovaries, for which endometrial biopsy was taken that showed non-secretory endometrium with atrophic changes. Tumor markers found to be normal. TAH+BSO was done and the histopathology showed Non-Hodgkin’s lymphoma, diffuse large B cell type of the endometrium and both ovaries which was confirmed by immune histochemical marker study. PET-CT was done that showed metabolically active para aortic and common iliac lymph nodes thereby she was diagnosed with stage II (Ann Arbor Staging) non-Hodgkin’s lymphoma, hence she received 6 cycles of R-CHOP. As evident in our case, non-Hodgkin’s Lymphoma of the endometrium and the ovaries being an extremely rare condition, high-degree of suspicion is required for its prompt diagnosis and treatment.


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