Ovarian tumor with mature teratoma with squamous differentiation in a postmenopausal female

Amrita Rai; Vijay Zutshi

doi:10.18203/2320-1770.ijrcog20174077

Authors

Amrita Rai Department of Obstetrics and Gynecology, Vardaman Mahavir Medical College, Safdarjung Hospital, New Delhi, India
Vijay Zutshi Department of Obstetrics and Gynecology, Vardaman Mahavir Medical College, Safdarjung Hospital, New Delhi, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20174077

Keywords:

Dermoid cyst, Mature cystic teratoma, Squamous cell carcinoma of ovary

Abstract

Mature cystic ovarian teratomas are the commonest germ cell tumour accounting for about 30-45% of all ovarian neoplasms and around 60% of all benign tumors arising in the ovary. The reported incidence of malignant transformation in MCT is approximately 2%. A rare case of squamous cell carcinoma arising in a dermoid cyst of the ovary presenting in a postmenopausal female is presented here. A 60-year-old postmenopausal lady, presented with the complaint of pain in lower abdomen for 2 years and a large complex abdomino-pelvic mass on examination and investigations. Final histopathology was reported as squamous cell carcinoma arising from mature cystic teratoma of right ovary. Primary cytoreductive surgery was done and a surgical stage IIB was assigned. In view of the poor prognosis, adjuvant chemotherapy was started.

Metrics

Metrics Loading ...

References

Tangjitgamol S, Manusirivithaya S, Sheanakul C, Leelahakorn S, Thawaramara T, Jesadapatarakul S. Squamous cell carcinoma arising from dermoid cyst: case reports and review of literature. Int J Gynecol Cancer. 2003;13(4)558-63.

Santos LD, Mok E, Iasonos A. Squamous cell carcinoma arising in mature cystic teratoma of the ovary: a case series and review of the literature. Gynecologic Oncol. 2007;105(2)321-4.

Hackethal A, Brueggmann D, Bohlmann MK, Franke FE, Tinneberg HR, Münstedt K. Squamous-cell carcinoma in mature cystic teratoma of the ovary: systematic review and analysis of published data. Lancet Oncol. 2009;10(5):446.

Koonings PP, Campbell K, Mishell DR, Grimes DA. Relative frequency of primary ovarian neoplasms: a 10-year review. Obstet Gynecol. 1989;74:921-6.

Whitecar MP, Turner S, Higby MK. Adnexal masses in pregnancy: a review of 130 cases undergoing surgical management. Am J Obstet Gynecol. 1999;181:19-24.

Caruso PA, Marsh MR, Minkowitz S, Karten G. An intense clinicopathologic study of 305 teratomas of the ovary. Cancer. 1971;27:343-8.

Blackwell WJ, Dockerty MB, Mason JC, Mussey RD. Dermoid cysts of the ovary: their clinical and pathological significance. Am J Obstet Gynecol. 1946;51:151-72.

Talerman A. Germ cell tumors of the ovary. In: Kurman RJ, ed. Blaustein’s pathology of the female genital tract. 4th ed. New York, NY: Springer-Verlag, 1994;849-914.

Matz MH. Benign cystic teratomas of the ovary. Obstet Gynecol Surv. 1961;16:591-605.

Kong CS, Longacre TA, Hendrickson MR. Philadelphia: Lippincott, Williams and Wilkins; Gynaecologic Oncol. 2012;38:176-8.

Comerci JT, Licciardo F, Bergh PA, Gregori C, Breen JL. Mature cystic teratoma: A clinicopathologic evaluation of 517 cases and review of the literature. Obstet Gynecol. 1994;84:22-8.

Ayhan A, Bukulmez O, Genc C, Karamursel BS, Ayhan A. Mature cystic teratomas of the ovary: Case series from one institution over 34 years. Eur J Obstet Gynecol Reprod Biol. 2000;88:153-7.

Hurwitz JL, Fenton A, McCluggage WG, McKenna S. Squamous cell carcinoma arising in a dermoid cyst of the ovary: A case series. BJOG. 2007;114:1283-7.

Kikkawa F, Nawa A, Tamakoshi K, Ishikawa H, Kuzuya K, Suganuma N, et al. Diagnosis of squamous cell carcinoma arising from mature cystic teratoma of ovary. Cancer. 1998;82:2249-55.

Kido A, Togashi K, Konishi I. Dermoid cysts of the ovary with malignant transformation: MR appearance. AJR Am J Roentgenol. 1999;172:445-9.

Yamashita Y, Hatanaka Y, Takahashi M, Miyazaki K, Okamura H. Struma ovarii: MR appearances. Abdom Imaging 1997;22:100-2.

Dohke M, Watanabe Y, Takahashi A, et al. Struma ovarii: MR findings. J Comput Assist Tomogr. 1997;21:265-7.

Hatanaka Y, Yamashita Y, Torashima M, Takahashi M. MR appearance of fat distribution in ovarian teratoma: pathologic correlation. Nippon Igaku Hoshasen Gakkai Zasshi 1996;56:477-81.

Kawakami S, Togashi K, Egawa H. Solid mature teratoma of the ovary: appearances at MR imaging. Comput Med Imaging Graph. 1994;18:203-7.

Comerci JT, Licciardi F, Bergh PA, Gregori C, Breen JL. Mature cystic teratoma: a clinicopathologic evaluation of 517 cases and review of the literature. Obstet Gynecol. 1994;84:22-8.

Brown MF, Hebra A, McGeehin K, Ross AJ III. Ovarian masses in children: a review of 91 cases of malignant and benign masses. J Pediatr Surg. 1993;28:930-3.

Takagi H, Ichigo S, Murase T, Ikeda T, Imai A. Early diagnosis of malignant — Transformed ovarian mature cystic teratoma: Fat-suppressed MRI findings. J Gynecol Oncol. 2012;23:125-8.

Linder D, McCaw BK, Hecht F. Parthenogenic origin of benign ovarian teratomas. N Engl J Med. 1975;292:63-6.

Caspi B, Appelman Z, Rabinerson D, Zalel Y, Tulandi T, Shoham Z. The growth pattern of ovarian dermoid cysts: a prospective study in premenopausal and postmenopausal women. Fertil Steril. 1997;68: 501-5.

Powell JR, Haldar K. Squamous cell carcinoma arising in a mature cystic teratoma of ovary: A case series and review of literature. Eur Oncol Hematol. 2013;9:17-20.

Mardi K, Sharma S. Squamous cell carcinoma arising in an ovarian mature cystic teratoma. Clin Cancer Investig J. 2014;3:96-8.

Madan M, Bhagat R, Agarwal AP, Sharma S. Squamous cell carcinoma arising in mature cystic teratoma: A rare case. Indian J Cancer. 2010;47:346-7.

Khajuria R, Bagotra M, Bhat R, Dubey VK. Squamous cell carcinoma arising in a cystic teratoma. J K Sci. 2000;2:110-2.

Santwani PM, Trivedi DP, Vachhani JH, Trivedi NJ. Coexistence of squamous cell carcinoma with dermoid cyst of ovary. Indian J Pathol Microbiol. 2008;51:81-2.