Thyroid profile in women with menstrual disorders

Madhu Digra, Ravinder Kumar, Dinesh Kumar


Background: Thyroid dysfunction influences both menstrual flow and fertility, likely through changes in sex hormone levels, gonadotrophin release and possibly ovarian function. Objectives of this work were to study thyroid related complaints and thyroid function tests in patients with menstrual irregularities like menorrhagia, oligomenorrhoea, amenorrhoea, hypomenorrhoea and ploymenorrhoea, to study menstrual patterns in women with diagnosed thyroid disease-hypothyroidism/hyperthyroidism and to study changes in menstrual patterns, if any in these patients during the course of treatment of thyroid disease, who receive correct treatment

Methods: This study was conducted in the Department of Obstetrics and Gynecology in Government L.D. Hospital, Government Medical College, Srinagar during the period from 2006 to 2007.  There were two groups under which the study was conducted. Group A: Seventy-five patients of DUB from Department of Gynecology in reproductive age group (15-45 years) presenting with menstrual irregularities like menorrhagia, oligomenorrhoea, amenorrhoea, hypomenorrhoea and ploymenorrhoea were studied for thyroid profile. Group B comprised of 25 patients including already diagnosed 17 hypothyroid and 8 hyperthyroid patients. The study protocol included thorough history taking, general physical examination, meticulous per speculum and pelvic examination and routine investigations like Hb, BT, CT, TLC, DLC, Platelet count and ABO-Rh in all patients, Serum T3, T4, TSH estimation.

Results: Most of the patients were in 35-45 years age group. Prevalence of infertility was more in hypothyroid group. 22.66% patients with DUB were detected as hypothyroid where as 13.33% patients were detected as hyperthyroid.

Conclusions: Thyroid function tests, many of which are sensitive radioimmunoassay, radiometric assays and even new chemiluminescence method, which can detect minute changes in hormone levels must be done in women presenting with menstrual disorders.


Menstrual disorders, Thyroid profile, Women

Full Text:



Adlersberg, Marcy A, Burrow, Gerard N. Focus on primary care thyroid function and dysfunction in women. Obstet Gynaecol Surv. 2002;57(3)Supplement:S1-S7.

Chu JP, You SS. Role of thyroid gland and oestrogen in regulation of gonadotrophic activity of anterior pituitary. J Endocrinology. 1945;115-124.

Scott JC, Mussey E. Menstrual patterns in myxedema. Am J Obst Gynae. 1964;90(2):161-5.

Russel KP. The current status of protein bound iodine in Obstetrics and Gynecology. Obstet Gynecol Surv. 1954;9:157.

Becks GP, Burrow GN. Diagnosis and treatment of thyroid disease during pregnancy. In: De Groot LJ, Editor, 3rd Edn. Philadelphia: Saunders; 1995:799-820.

Mandel SJ, Brent GA, Larsen PR. Review of antithyroid drug use during pregnancy.1994;4:129-133.

Pilli GS, Sethi B, Dhaded AV, Mathur PR. Dysfunctional uterine bleeding. J Obstet Gynecol India. 2002;52(3):87 -89.

Mehrota VG, Mukherjee K, Pandey M, Samant V. J Obstet Gynecol India. 1972;12:684.

Doifode CD, Fernandes K. Study of thyroid dysfunction in patients with dysfunctional uterine bleeding. J Obstet Gynecol India. 2001;51(2):93-95.

Muzzaferri EL. Evaluation and management of common thyroid disorders in women. Am J Obst Gynecol. 1997;176 (3):507-514.

Mukherjee K and Ghosh AK. Thyroid, prolactin related menstruation. J Obstet Gynecol India. 1985;35:549-52.

Willansky DL, Greisman B. Early hypothyroidism in patients with menorrhagia. Am J Obstet Gynecol. 1989;160(3):673-7.

Lahiri D, Dasgupta A, Kunda S. Menstrual pattern and fertility status in hypothyroidism. J Obstet Gynecol India. 1996;47:663.

Menon VK, Bharucha KE. Menstrual dysfunction and thyroid disease. J Obstet Gynecol India. 1995;45 (4):521-6.

Singh L, Agarwal CS, Chowdery SR, Mehra P, Khare R. Thyroid profile in infertile women. J Obst Gynae India. 1990;40:248-53.

Scott JC, Mussey E. Menstrual patterns in myxedema. Am J Obstet Gynecol. 1964;90(2):161-5.

Means JH. The thyroid and its diseases. Edn. 2nd. Philadelphia. JB Lippincott Co; 1948:571.

Kleinberg DL, Noel G, Frantz AG. Galactorrhea: a study of 235 cases, including 48 with pituitary tumors. N Engl J Med. 1977;296(11):589-600.

Benson RC, Dailey ME. Menstrual pattern in hyperthyroidism and subsequent post therapy hypothyroidism. Surg Gynecol Obstet. 1955;100:19-26.