Serum estradiol level and postmenopausal symptoms in surgical and natural menopause

Authors

  • Navdeep Kaur Department of Obstetrics and Gynecology, PGIMER, Dr Ram Manohar Lohia Hospital, New Delhi, India
  • Veena G. Malla Department of Obstetrics and Gynecology, PGIMER, Dr Ram Manohar Lohia Hospital, New Delhi, India
  • Sonal Gupta Department of Obstetrics and Gynecology, PGIMER, Dr Ram Manohar Lohia Hospital, New Delhi, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20174035

Keywords:

Natural menopause, Postmenopausal symptoms, Serum estradiol, Surgical menopause

Abstract

Background: Menopause whether it occurs naturally or surgically is characterized by the reduced production of hormones by the ovaries. The study aimed at comparing the serum estradiol levels and postmenopausal symptoms in women with surgical and natural menopause.

Methods: 50 women each of natural and surgical menopause were enrolled. Five ml of fasting blood sample was collected from each patient in both the groups by venepuncture in a plain tube, which was centrifuged and was analyzed for serum estradiol levels by chemiluminescence method. Levels of serum estradiol hormone for both the groups were compiled and the mean and standard deviation was calculated. Postmenopausal symptoms were also compared among two groups. Chi square and fisher exact test were used to analyze the qualitative data and t test were used to analyze the quantitative data.

Results: The mean level of serum estradiol in women with surgical menopause was found to be 20.49 + 3.16 pg/ml while that in natural menopause, was 27.41 + 5.08pg/ml. The difference in mean estradiol level between the two groups was found to be statistically significant (p value <0.0001). Hot flushes and mood swings were observed in more number of women with surgical menopause.

Conclusions: The statistically significant lower levels of serum estradiol in surgical menopausal group may be a reason behind increased presence of menopausal symptoms in this group. Thus, the women in this group may benefit from hormone replacement therapy, improving their quality of life, however further studies are needed to establish this role.

References

Appt SE, Clarkson TB, Hoyer PB, Kock ND, Goode AK, May MC et al. Experimental induction of reduced ovarian reserve in a non-human primate model. Comp Med. 2010;60(5):380-8.

Pal A, Hande D, Khatri S. Assessment of menopausal symptoms in perimenopause and post menopause women above 40 years in rural area. Internat J Healthc Biomedic Res. 2013;1(3):166-74.

Simpson ER. Sources of estrogen and their importance. J steroid Biochem Molecul Biol. 2003;86:225-30.

Padubidri VG, Daftary SN. Perimenopause, Menopause, Premature menopause and Postmenopausal bleeding. Howkins and Bourne Shaw’s textbook of Gynecology. 15th ed. New Delhi: Elsevier India Pvt Ltd; 2011:62.

Naik R, Chandel Rittu S, Abichandani LG. Comparison of serum estradiol levels in surgical and natural menopause. IOSR. 2014;9(1):65-67.

Menopause Terminology. Indian Menopause Society. WHO, 2015. Available from: www.imsociety.org/menopause_terminology.php#.Accessed 6 april2016

Fogle R, Stanczyk FZ, Zhang X, Paulson RJ. Ovarian androgen production in postmenopausal women. JCEM. 2013;92(8):3040-43.

Kate MB. Can hysterectomy be considered a risk factor for cardiovascular disease. Circulation. Journal of American heart association. 2005;111:1456-8.

Kabir F, Jahan N, Sultana N, Akter R. Lipid profile status in surgical menopause. J Bangladesh Soc Physiol. 2011;6(2):127-33

Furuhashi N, Abe T, Suzuki M. Changes in Hypophysio-ovarian Endocrinological Function of Post-menopausal and Surgical menopausal women In Tohoku J Med. 1976;120;19-24.

Pearce J, Hawton K, Blake F. Psychological and sexual symptoms associated with the menopause and the effects of hormone replacement therapy. Br J Psych. 1995;167:163-73.

Bachmann GA. Vasomotor flush in menopausal women. Am J Obstet Gynecol. 1999;180:S312-6.

Nachtigall LE. Preoperative care and patient evaluation. Proceedings of the 1996 annual meeting of the American College of Obstetricians and Gynaecologists;1996.

Naik R, ChandelRittu S, Abichandani LG. Comparative study of gonadotropin levels and clinical presentation in surgical and natural menopause. Internat J Medic Res Health Sci. 2014;3(1):149-54.

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Published

2017-08-28

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Original Research Articles