DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20174081

Adrenal gland metastasis - an unusual manifestation of cancer cervix

Deenadayalan Theivasikamani, Lakshminarasimhan Srinivasan, Ramkumar Bakthavachalam

Abstract


Cancer Cervix is the most common women related cancer in India. It mainly affects middle aged female of 40-55 years age group, largely attributed to HPV infection. Advances in radiation therapy, surgical techniques and chemotherapy, have resulted in improved survival rates. Still 20-30% patients with cancer cervix would develop recurrent or persistent disease. Although the typical manifestations of recurrent cervical carcinoma are pelvic masses and lymphadenopathy, less typical manifestations like solid organ metastases and peritoneal carcinomatosis also can occur. The increasing prevalence of these less typical manifestations is partially related to the use of intensive pelvic radiation therapy, resulting in a shift away from pelvic recurrence toward distant metastasis, as well as related to improvements in cross-sectional imaging techniques. This article describes a clinical case of a 40-year-old patient with cancer cervix, who achieved complete remission with concurrent chemo radiotherapy and 3 years later, she relapsed with adrenal metastasis.


Keywords


Adrenal metastasis, Cancer Cervix, Chemotherapy, Radiotherapy, Relapse

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References


Ries LAG, Harkins D, Krapcho M. SEER Cancer Statistics Review, 1975 to 2003. National Cancer Institute, Bethesda, MD; 2006. Available at https://seer.cancer.gov/archive/csr/1975_2003/results_merged/sect_05_cervix_uteri.pdf

National Cancer Registry Programme (NCRP, ICMR). Time trends in cancer incidence rates:1982-2005. Bangalore: NCRP; 2009. Available at http://ncrpindia.org/Annual_Reports.aspx

Nandakumar, Ramnath T, Chaturvedi M. The magnitude of cancer cervix in India National Cancer Registry Programme (ICMR), Bangalore, India; 2009. Available at http://medind.nic.in/iby/t09/i9/ibyt09i9p219.pdf

ICO Information Centre on HPV and Cancer India Human Papillomavirus and Related Cancers, Fact Sheet; 2017. Available at http://www.hpvcentre.net/statistics/reports/IND_FS.pdf

Burghardt E, Baltzer J, Tulusan AH, Haas J. Results of surgical treatment of 1028 cervical cancers studied with volumetry. Cancer. 1992;70(3):648-55.

Ann S. Fulcher, Susan G. O'Sullivan, Eileen M. Segreti, Brian D. Kavanagh. Recurrent Cervical Carcinoma: Typical and Atypical Manifestations RSNA Radiographics; 1999.

Straughn JM. Invasive cervical cancer: Patterns of recurrence and posttreatment surveillance. Available at http://www.uptodate.com/contents/invasive-cervical-cancer-patterns-of-recurrence-and-posttreatment-surveillance

Baron M, Hamou L, Laberge S, Callonnec F, Tielmans A, Dessogne P. Metastatic spread of gynaecological neoplasms to the adrenal gland: case reports with a review of the literature Eur J Gynaecol Oncol. 2008;29(5):523-6.

Friedlander M, Grogan M. U. S. Preventative Services Task Force. Guidelines for the treatment of recurrent and metastatic cervical cancer. Oncologist. 2002;7:342.

Gadducci A, Tana R, Cosio S, Cionini L. Treatment options in recurrent cervical cancer (Review). Oncol Lett. 2010;1(1)3-11.

Van Nagell JR, Rayburn W, Donaldson ES, Hanson M, Gay EC, Yoneda J, et al. Therapeutic implications of patterns of recurrence in cancer of the uterine cervix. Cancer. 1979;44(6):2354-61.

Leitao MM, Chi DS. Recurrent cervical cancer. Curr trat Options Oncol. 2002;3(2):105-11.

Kamura T, Ushijima K. Chemotherapy for advanced or recurrent cervical cancer; Taiwanese. J Obstet Gynecol. 2013;23