Overview of liver disorders during pregnancy at a tertiary care centre: Uttarakhand scenario

Monika Ramola, Shweta Jain, Vineeta Gupta, Neeta Bansal, Parul Singh


Background: Liver disorders in pregnancy encompass a spectrum of diseases encountered during antenatal and postnatal period resulting in abnormal liver function tests and hepatobiliary dysfunction or both. This study is aimed at determining the causes of liver disorders during pregnancy and associated maternal and fetal outcomes over a period of 3 years at a tertiary care centre of Dehradun.

Methods: All case records of patients with liver disorders during pregnancy from May 2013 to May 2016 were retrieved from medical record department of SGRRIMHS, Dehradun and analyzed for various causes of liver disorders and associated maternal and fetal outcomes.

Results: During the three-year study period, 146 pregnant patients were found to have liver disorders. The study found that viral hepatitis was the most common cause of liver disorders followed by Intrahepatic cholestasis of pregnancy IHCP. There were 6 mortalities among the study group out of which hepatitis E was the culprit for maternal mortality in two patients. The serum bilirubin levels were directly proportional to the maternal deaths.

Conclusions: Liver disorders during pregnancy are rare but an important cause of maternal and fetal morbidity and mortality. Early recognition, timely referral and aggressive management may lead to better maternal and fetal outcome.


Acute fatty liver of pregnancy (AFLP), DIC (Disseminated intravascular coagulation), HELLP (Hemolysis, elevated liver enzymes and low platelet count), ICU (Intensive care unit), Intrahepatic cholestasis of pregnancy (IHCP), Liver disorders

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