Association of metabolic syndrome and lower urinary tract symptoms amongst South Indian postmenopausal women
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20174411Keywords:
Body composition, DEXA scan, LUTS, Metabolic syndrome, Postmenopausal womenAbstract
Background: Women spend one third of their life in menopause. The age related anatomical and physiological changes predispose them to MetS and lower urinary tract symptoms (LUTS). The aim was to study the prevalence of metabolic syndrome (MetS) and lower urinary tract symptoms in postmenopausal women attending menopause clinic, to study the correlation of LUTS and body composition among women with MetS.
Methods: 154 post-menopausal women who attended menopause clinic at the Christian Medical College Hospital Vellore, were recruited. MetS was diagnosed using IDF criteria. LUTS were assessed BFLUTS questionnaires. Blood was taken to assess serum fasting glucose and lipid profile. DEXA was performed to assess the whole-body composition.
Results: Of 154 postmenopausal women, 64% had MetS and 43% of women had a total LUTS score > 5. 90% of women had filling symptoms,57% had incontinence,17% had voiding symptoms,14 % had quality of life issues and 6 % had sexual symptoms. However, there was no statistical significant difference between two groups in correlating the variables of MetS with LUTS (P >0.05). The percentage of total body fat by DEXA scan was significantly greater (P=0.006) in women with MetS (37.32±5.04) when compared to the women without MetS (34.629±3.65).
Conclusions: Prevalence of MetS among the study population was 64 %. LUTS were observed in 43% of the patients. There was no significant difference in LUTS in women with MetS and without Mets. However, there was a significant difference in body composition among women with and without MetS.
References
Mesch VR, Boero LE, Siseles NO, Royer M, Prada M, Sayegh F et al. Metabolic syndrome throughout the menopausal transition: influence of age and menopausal status. Climacteric. 2006;9(1):40-8.
Gorbachinsky I, Akpinar H, Assimos DG. Metabolic syndrome and urologic diseases. Rev Urol. 2010;12(4):e157.
Gökkaya CS, Özden C, Aktaş BK, Demirel HC, Güzel Ö, Karabakan M et al. The correlation between metabolic syndrome and lower urinary tract symptoms in females. Turkish J Med Sci. 2013;43(3):400-4..
Alberti KG, Zimmet P, Shaw J. Metabolic syndrome—a new world‐wide definition. A consensus statement from the international diabetes federation. Diabetic Med. 2006;23(5):469-80.
Brookes ST, Donovan JL, Wright M, Jackson S, Abrams P. A scored form of the Bristol Female lower urinary tract symptoms questionnaire: data from a randomized controlled trial of surgery for women with stress incontinence. Am J Obstet Gynecol. 2004;191(1):73-82.
Burger HG, Dudley EC, Robertson DM, Dennerstein L. Hormonal changes in the menopause transition. Recent Progress Hormone Res. 2002;57:257-76.
Heidari R, Sadeghi M, Talaei M, Rabiei K, Mohammadifard N, Sarrafzadegan N. Metabolic syndrome in menopausal transition: Isfahan Healthy Heart Program, a population based study. Diabetol Metab Syndr. 2010 Oct 5;2(1):59.
Figueiredo Neto JA, Figuerêdo ED, Barbosa JB, Barbosa FD, Costa GR, Nina VJ et al. Metabolic syndrome and menopause: cross-sectional study in gynecology clinic. Arquivos Brasileiros de Cardiologia. 2010 Sep;95(3):339-45.
Pandey S. Menopause and metabolic syndrome: A study of 498 urban women from western India. J. -Life Health. 2010;1:63-69.
Marchi RD, Dell’Agnolo CM, Lopes TC, Gravena AA, Demitto MD, Brischiliari SC et al. Prevalence of metabolic syndrome in pre-and postmenopausal women. Arch Endocrinol Metab. 2017 Mar-Apr;61(2):160-166.
Peppa M, Koliaki C, Dimitriadis G. Body composition as an important determinant of metabolic syndrome in postmenopausal women. Endocrinol Metab Syndrome. 2012:2161-1017.
Cellek S, Rodrigo J, Lobos E, Fernández P, Serrano J, Moncada S. Selective nitrergic neurodegeneration in diabetes mellitus–a nitric oxide‐dependent phenomenon. Br J Pharmacol. 1999;128(8):1804-12.
Uzun H, Zorba OÜ. Metabolic syndrome in female patients with overactive bladder. Urology. 2012;79(1):72-5.
Temml C, Obermayr R, Marszalek M, Rauchenwald M, Madersbacher S, Ponholzer A. Are lower urinary tract symptoms influenced by metabolic syndrome?. Urology. 2009;73(3):544-8.
Ponholzer A, Temml C, Rauchenwald M, Marszalek M, Madersbacher S. Is the metabolic syndrome a risk factor for female sexual dysfunction in sexually active women?. Int J Impotence Res. 2008;20(1):100.
Esposito K, Giugliano D. Obesity, the metabolic syndrome, and sexual dysfunction in men. Clin Pharmacol Therapeut. 2011;90(1):169-73.
Kupelian V, McVary KT, Kaplan SA, Hall SA, Link CL, Aiyer LP et al. Association of lower urinary tract symptoms and the metabolic syndrome: results from the Boston Area Community Health Survey. J Urol. 2013;189(1):S107-16.
Wennberg AL, Molander U, Fall M, Edlund C, Peeker R, Milsom I. Lower urinary tract symptoms: lack of change in prevalence and help‐seeking behaviour in two population‐based surveys of women in 1991 and 2007. BJU International. 2009 Oct 1;104(7):954-9.
Tai HC, Chung SD, Ho CH, Tai TY, Yang WS, Tseng CH et al. Metabolic syndrome components worsen lower urinary tract symptoms in women with type 2 diabetes. J Clin Endocrinol Metab. 2010;95(3):1143-50.
Toth MJ, Tchernof A, Sites CK, Poehlman ET. Effect of menopausal status on body composition and abdominal fat distribution. Int J Obes. 2000;24(2):226.
Dasgupta S, Salman M, Lokesh S, Xaviour D, Saheb SY, Prasad BR et al. Menopause versus aging: The predictor of obesity and metabolic aberrations among menopausal women of Karnataka, South India. J Mid-life Health. 2012;3(1):24.
Ibrahim MM. Subcutaneous and visceral adipose tissue: structural and functional differences. Obes Rev. 2010;11(1):11-8.
Kaul S, Rothney MP, Peters DM, Wacker WK, Davis CE, Shapiro MD et al. Dual‐energy X‐ray absorptiometry for quantification of visceral fat. Obesity. 2012;20(6):1313-8.
Gavi S, Feiner JJ, Melendez MM, Mynarcik DC, Gelato MC, McNurlan MA. Limb fat to trunk fat ratio in elderly persons is a strong determinant of insulin resistance and adiponectin levels. J Gerontol Series A: Biologic Scie Med Sci. 2007;62(9):997-1001.
Van Pelt RE, Evans EM, Schechtman KB, Ehsani AA, Kohrt WM. Contributions of total and regional fat mass to risk for cardiovascular disease in older women. Am J Physiol-Endocrinol Metab. 2002;282(5):E1023-8.
