Malignant placental trophoblastic tumour a diagnostic dilemma: rare association with focal segmental glomerulonephritis and cardiomyopathy
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20174471Keywords:
Placental site trophoblastic tumor, Glomerulonephritis (GN), Gestational trophoblastic neoplasia, Trophoblastic neoplasiaAbstract
Placental site trophoblastic tumour (PSTT) is the rarest form of Gestational trophoblastic neoplasia (GTN).It has a wide clinical spectrum of presentation and its complications have a multi organ involvment. Inspite of the advances in HCG assays and sensitive unltrasounds, its diagnosis and course in every case is a mystery. However, it is only rarely associated with glomerulonephritis. Most cases have not been biopsied and the specific nature of renal involvement is not clearly understood. Here we report a case of PSTT with glomerulonephritis and cardiomyopathy.
References
Cole ME, Broaddus R, Thaker P, Landen C, Freedman RS. Placental-site trophoblastic tumors: a case of resistant pulmonary metastasis. Nature Reviews. Clin Oncol. 2008;5(3):171.
Piura B. Placental site trophoblastic tumor e a challenging rare entity. Eur J Gynecol Oncol. 2006;27(6):545-551.
Xiao C, Zhao J, Li M, Zhao D, Xiang Y. Lupus nephritis associated with placental site trophoblastic tumor: A case report and review of the literature. Gynecol Oncol Case Rep. 2014;9:26-28.
Huang F, Zheng W, Liang Q, Yin TDiagnosis and treatment of placental site trophoblastic tumor. Int J Clin Exp Pathol. 2013;6(7):1448-51.
Lan C, Li Y, He J, Liu J. Placental site trophoblastic tumor: lymphatic spread and possible target markers. Gynecol Oncol. 2010;116(3):430-7.
Feltmate CM, Genest DR, Wise L, Bernstein MR, Goldstein DP, Berkowitz RS. Placental site trophoblastic tumor: a 17-year experience at the New England Trophoblastic Disease Center. Gynecol Oncol. 2001;82:415-9.
Hui P, Parkash V, Perkins AS, Carcangiu ML. Patho- genesis of placental site trophoblastic tumor may require the presence of a paternally derived X chromosome. Lab Invest. 2000;80(6):965-972.
Muller-Hocker J, Obernitz N, Johannes A, Lohrs U. p53 gene product and EGF receptors are highly expressed in placental site trophoblastic tumor. Hum Pathol. 1993;28(11):1302-6.
Baergen RN, Rutgers JL, Young RH, Osann K, Scully RE. Placental site trophoblastic tumor: a study of 55 cases and review of the literature emphasizing factors of prognostic significance. Gynecol Oncol. 2006;100:511-520.
Agarwal N, Parul Kriplani A, Vijayaraghavan M. Placental site trophoblastic tumour. J Postgrad Med. 2002;48(3):211.
Mazzucco G, Colla L, Monga G. Kidney involvement in a patient affected by placental site trophoblastic tumor. Am J Kidney Dis. 2011;57:516-520.
Yang JW, Choi SO, Kim BR. Nephrotic syndrome associated with invasive mole: a case report. Nephrol. Dial. Transplant. 2010;25:2023-6.
Batra V, Kalra OP, Mathur P. Membranous glomerulopathy associated with placental site trophoblastic tumour: a case report. Nephrol Dial Transplant. 2007;22:1766-8.
Altiparmak MR, Pamuk ON, Pamuk GE. Membranous glomerulonephritis in a patient with choriocarcinoma: case report. South Med J. 2003;96:198-200.
Komatsuda A, Nakamoto YK. A Case report: nephrotic syndrome associated with a total hydatidiform mole. Am J Med Sci. 1992;303:309-312.
Young RH, Scully RE, McCluskey RT. A distinctive glomerular lesion complicating placental site trophoblastic tumor: report of two cases. Hum Pathol. 1985;16:35-42.