Efficacy of low dose aspirin on maternal and foetal outcome in preeclampsia


  • Sopanrao Malharrao Togarikar Department of Obstetrics and Gynecology, MNR Medical College and Hospital, Sangareddy, Telangana, India




Aspirin, Blood pressure, Platelet count, Preeclampsia, Proteinuria


Background: Low dose aspirin administration can reduce vasoconstriction and decreases thrombosis of the vessels related to placenta, thereby increases blood flow and protects against to pregnancy related complication like preeclampsia, IUGR or FGR. This study was undertaken to assess the efficacy of low dose aspirin (75 mg/day) on foetal and maternal outcome in preeclampsia patients.

Methods: A total 100 preeclampsia patients were elected and were divided in to two groups i.e. control group includes age and parity matched preeclampsia cases under regular conventional treatment without aspirin administration and cases group receiving conventional treatment with aspirin 75 mg/ day after breakfast from recruitment upto one week before pregnancy.

Results: There was a significant decrease in caesarean sections in cases (22%) and control groups (30%). Blood pressure, proteinuria was significantly reduced and platelets count was increased at time of presentation to after delivery in cases and controls. There was a less intra uterine deaths (8% in cases and 14% in controls) and neonatal deaths (2% in cases and 6% in controls) in cases than in controls. Neonatal haemorrhage was not accounted in both groups.

Conclusions: Beginning of low dose aspirin administration in the early second trimester of pregnancy may reduce incidence of adverse health outcomes like IUGR, preeclampsia and preterm birth.


Bartsch E, Park AL, Kingdom JC, Ray JG. Risk threshold for starting low dose aspirin in pregnancy to prevent preeclampsia: An opportunity at a low cost. PLoS One. 2015;10:e0116296.

Lowe SA, Bowyer L, Lust K, McMahon LP, Morton MR, North RA et al. The SOMANZ guidelines for the management of hypertensive disorders of pregnancy 2014. Aust N Z J Obstet Gynecol. 2015;55:11-16.

Sammar D, Syngelaki A, Sharabi-Nov A, Nicolaides K, Meiri H. Can staining of damaged proteins in urine effectively predict preeclampsia? Fetal Diagn Ther. 2017;41(1):23-31.

Abalos E, Cuesta C, Grosso AL, Chou D, Say L. Global and regional estimates of preeclampsia and eclampsia: A systematic review. Eur J Obstet Gynecol Reprod Biol. 2013;170:1-7.

LeFevre ML. Low-Dose aspirin use for the prevention of morbidity and mortality from preeclampsia: U.S. Preventive Services Task Force recommendation statement. Annal Intern Med. 2014;161(11):819-826.

Haapsamo M, Martikainen H, Rasanen J. Low-dose aspirin reduces uteroplacental vascular impedance in early and mid-gestation in IVF and ICSI patients: a randomized, placebo controlled double-blind study. Ultrasound Obstet Gynecol. 2008;32:687-693.

Espinoza J, Romero R, Mee Kim Y, Kusanovic JP, Hassan S, Erez O et al. Normal and abnormal transformation of the spiral arteries during pregnancy. J Perinat Med. 2006;34:447-458.

Pritchard JA, MacDonald PC. Hypertensive disorders in pregnancy. Williams’s obstetrics, 16th Ed;1990:665-700.

Downing I, Shepheres GL, Lewis PJ. Reduced prostacyclin production in preeclampsia. Lancet. 1981;2:1374.

McParland P, Pearce JM, Chamberlain GV. Doppler ultrasound and aspirin in recognition and prevention of pregnancy-induced hypertension. Lancet. 1990;335(8705):1552-5.

Katz UI, Thorp JM, Razas I, Bowes WA. The natural history of thrombocytopenia associated with preeclampsia. Am J Obstet Gynecol. 1990;163:1142.

Uzan S, Beaufils M, Breast G, bagin B. Prevention of fetal growth retardation with low dose aspirin: findings of EPREDA trial. Lancet. 1991;337(8755):1427-31.

Toppozada M, Darwish EA, Osman YF. Low dose acetyl salicylic acid in severe preeclamsia. Int J Gynecol Obstet. 1991;38:311-7.

Wallenberg HCS, Rotmans N. Prevention of recurrent idiopathic fetal growth retardation by low ose aspirin and dipyridamole. Am J Obstet Gynecol. 1987;157:1230.

Schiff E, Edena P, Goldenberg M, Rosenthal T, Ruppin E, Tamarkin M et al. The use of aspirin to prevent pregnancy induced hypertension and lower the ratio of thromboxane A2 to prostacyclin in relatively high pregnancies. N Eng J Med. 1989;321:351-6.

Trudinger BJ, Cook CM, Thompson RS, Giles WB, Connelly A. Low dose aspirin therapy improves fetal weight in umblical placental insufficiency. Am J Obstet Gynecol. 1988;159:681-5.

Benigni A, Gregini G, Frusca T, Chiabrando C, Ballerini S, Valcamonico A et al. Effect of low dose aspirinon fetal and maternal generation of thromboxane by platelets in women at risk for pregnancy induced hypertension. N Engl J Med. 1989;321:357-62.






Original Research Articles