Colposcopic evaluation of unhealthy cervix and it’s correlation with Papanicolau smear in cervical cancer screening
Keywords:Abnormal cervix, Cervical cancer screening, Colposcopy, PAP smear
Background: In present study colposcopic evaluation of unhealthy cervix was donr and it’s correlation with Papanicolau smear in screening of Cancer cervix. Objective of present study was to critically evaluate the sensitivity and specificity of PAP smear with that of Colposcopy in screening of Cancer Cervix in women with unhealthy cervix.
Methods: 100 women with clinically unhealthy cervix on naked eye examination and / or abnormal symptoms attending Gynaecology Out patient department in 2 years period were subjected to PAP smear, Colposcopy, biopsies under Colposcopic guidance and findings correlated with Histopatholgy at Govt. Medical college, Aurangabad, Maharashtra. India. The sensitivity and specificity of PAP smear with that of Colposcopy in screening of Cancer Cervix was evaluated.
Results: Both PAP smear and Colposcopy can be reliably used to screen women with premalignant lesions of Cancer cervix.
Conclusions: Colposcopy is a better tool for diagnosis of precursors of Cancer Cervix than PAP Smear and Histopathology of suspected lesion remains the gold standard for final diagnosis.
Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBCAN 2008. Int J Cancer. 2010;127:2893-917.
World health organization. Comprehensive cervical cancer control: A guide to essential practice. Geneva: WHO; 2006:13-23.
Pandey K, Bhogoliwal A: Cancer cervix- need for mass surveillance program specially in Rural areas. J Obstet Gynecol India. 2005;55(5):436-9.
Goel A, Gandhi G, Batra S, Bhambani S, Zutshi V, Sachdeva P. Visual inspection of the cervix with acetic acid for cervical Intraepithelial lesions. Dept of Obstetrics and Gynaecology, Maulan Azad medical college, new Delhi, India. Int J Gynecol Obstet. 2005;88(1):25-30.
Durdi GS, Sherigar BY, Dalal AM, Desai BR, Malur PR. Correlation of colposcopy using Reid colposcopic index with histopathology-a prospective study. J Turkish-German Gynecol Assoc. 2009;10:205-7.
Ashmita D, Shakuntala PN. Comparison and Correlation of PAP Smear, Colposcopy and Histopathology in Symptomatic Women and Suspicious Looking Cervix in a Tertiary Hospital Care Centre. IJHSR. 2013;3(5):50-9.
Shanta V, Krishnamurthi S, Gajalakshmi CK, Swaminathan R, Ravichandran K. Epidemiology of cancer of the cervix: global and national perspective. J Indian Med Assoc. 2000 Feb;98(2):49-52.
Mohanty J, Mohanty BK. Risk factors in Invasive carcinoma of cervix. J Obstet Gynecol India. 1991:403-6.
Parvin S, Kabir N, Lipe YS, Nasreen K, Alam KN. Correlation of pap smear and colposcopic finding of cervix with histopatholgiocal report in a group of patient attending in a tertiary hospital. J Dhaka Med Coll. 2013 Jul 7;22(1):39-44.
Bharti B., Satish P. Role of Colposcopy In Evaluation of Lower Female Genital Tract in 175 Symptomatic Women. J Obstet Gynecol India. 2004;54:372.
Denny L, Kuhn L, Pollack A, Wainwright H, Wright TC. Evaluation of alternative methods of cervical cancer screening for resource‐poor settings. Cancer. 2000 Aug 15;89(4):826-33.
Shastri SS, Dinshaw K, Amin G, Goswami S, Patil S, Chinoy R et al. Concurrent evaluation og Visual cytological and HPV testing as screening methods for the early detection of cervical neoplaisia in Mumbai, India. Bull World Healthy Organ. 2005;83(3):186-94.
Sherwani RK, Khan T, Akhtar K, Zeba A, Siddique FA, Rahman K et al. Conventional PAP smear and liquid based cytology for cervical cancer screening-a comparative study. J Cytol. 2007;24(4):167-172.
Sankaranarayanan R, Basu P, Wesley RS, Mahe C, Keita N, Mbalawa CC et al. Accuracy of visual screening for cervical neoplasia: Results from an IARC multicentre study in India and Africa. Int J Cancer. 2004 Jul 20;110(6):907-13.
Arora R, Vijaya K, Habeebullah S, Asha O, Colposcopic evaluation of unhealthy cervix. J Obstet Gynecol Ind. 2000;50:102-3.
Zarchi MK, Binesh F, Kazemi Z, Teimoori S, Soltani HR, Chiti Z. Value of colposcopy in the early diagnosis of cervical cancer in patients with abnormal pap smears at Shahid Sadoughi hospital, Yazd. Asian Pacific J Cancer Preven. 2011 Jan 1;12(12):3439-41.
Pimple SA, Amin G, Goswami S, Shastri SS. Evaluation of colposcopy vs cytology as secondary test to triage women found positive on visual inspection test. Indian J Cancer. 2010 Jul 1;47(3):308.
Basu PS, Sankaranarayanan R, Mandal R, Roy C, Das P, Choudhury D et al. Visual inspection with acetic acid and cytology in the early detection of cervical neoplasia in Kolkata, India. Int J Gynecol Cancer. 2003 Sep 1;13(5):626-32.
Ghosh P, Gandhi G, Kochhar PK, Zutshi V, Batra S. Visual inspection of cervix with Lugol's iodine for early detection of premalignant & malignant lesions of cervix. The Indian J Med Res. 2012 Aug;136(2):265.