Mixed Mullerian tumor: a case report

Mahrukh Nazneen, Uma N. Wankhede


Malignant mixed Müllerian tumor, also known as malignant mixed mesodermal tumor, MMMT and carcinosarcoma, is a malignant neoplasm found in the uterus, the ovaries, the fallopian tubes and other parts of the body that contains both carcinomatous (epithelial tissue) and sarcomatous (connective tissue) components. A 50-year female P1L1A1 with complaints of pervaginum bleeding and pain in abdomen was diagnosed to have carcinosarcoma endometrium for which hysterectomy with bilateral salphingo-opherectomy was done.


Carcinosarcoma, Hysterectomy, Malignant mixed Mullerian tumor

Full Text:



Brooks SE, Zhan M, Cote T, Baquet CR. Surveillance, epidemiology, and end results analysis of 2677 cases of uterine sarcoma 1989-1999. Gynecol Oncol. 2004;93:204-8.

El-Nashar SA, Mariani A. Uterine carcinosarcoma. Clin Obstet Gynecol. 2011;54(2):292-304.

Meyer R. In Veit-Stoeckel. 1930;6:770-4.

Bosquet JS, Terstrie SA, Cliby WA, Brown-Jones M, Kaur JS, Podratz KC, et al. The impact of multi-modal therapy on survival for uterine carcinosarcomas. Gynecol Oncol. 2010;116(3):419-23.

Ahuja A, Safaya R, Prakash G, Kumar L, Shukla, NK. Primary mixed Mullerian tumor of the vagina: a case report with review of the literature. Pathology Research and Practice. 2011;207(4):253-5.

Sharma NK, Sorosky JI, Bender D, Fletcher MS, Sood AK. Malignant mixed Mullerian tumor (MMMT) of the cervix. Gynecol Oncol. 2005;97(2):442-5.

Duman BB, Kara IO, Gunaldi M, Ercolak V. Malignant mixed Mullerian tumor of the ovary with two cases and review of the literature. Arch Gynecol Obstet. 2011;283(6):1363-8.

Shen YM, Xie YP, Xu L. Malignant mixed Mullerian tumor of the fallopian tube: report of two cases and review of literature. Arch Gynecol Obstet. 2010;281(6):1023-8.

de Jong RA, Nijman HW, Wijbrandi TF, Reyners AK, Boezen HM, Hollema H. Molecular markers and clinical behavior of uterine carcinosarcomas: focus on the epithelial tumor component. Modern Pathology. 2011;24(10):1368.

Jin Z, Ogata S, Tamura G. Carcinosarcomas (malignant Mullerian mixed tumors) of the uterus and ovary: a genetic study with special reference to histogenesis. Int J Gynecol Pathol. 2003;22(4):368-73.

McCluggage WG. Malignant biphasic uterine tumors: carcinosarcomas or metaplastic carcinomas? J Clin Pathol. 2002;55:321-5.

Brown L. Pathology of uterine malignancies. Clin Oncol. 2008;20(6):433-47.

Mayall F, Rutty K, Campbell F. p53 immunostaining suggests that uterine carcinosarcomas are monoclonal. Histopathol. 1994:24:211-4.

Szukala SA, Marks JR, Burchette JL. Coexpression of p53 by epithelial and stromal elements in carcinosarcoma of the female genital tract: an immunohistochemical study of 19 cases. Int J Gynecol Cancer. 1999;9:131-6.

George E, Manivel JC, Dehner LP. Malignant mixed Mullerian tumors: an immunohistochemical study of 47 cases, with histogenetic considerations and clinical correlation. Hum Pathol. 1991;22:215-23.