Published: 2017-11-23

A rare case of severe hypertriglyceridemia induced pancreatitis in pregnancy

Poonam Kashyap, Sudha Prasad, Chandra Bhushan Singh


Acute pancreatitis is caused by various causes such as Gall stone disease, alcoholism, drug abuse but rarely caused by severe hypertriglyceridemia. It typically presents as acute or recurrent pancreatitis. The hypertriglyceridemia can be gestation induced or familial. The family history of the pregnant women needs to be taken in detail. The serum triglyceride levels in the range of 1000 to 2000 mg/dl in patients with type I, III, IV and V hyperlipoproteinemia (Friedrickson's classification) is the identifiable risk factor. The clinical course of hypertriglyceridemia induced pancreatitis is similar to other causes. We hereby report a case of 21-year-old lady G3P1L0A1 with 37 weeks of pregnancy without any family history of hypertriglyceridemia and but with history of recurrent episodes of acute pancreatitis.


Hypertriglyceridemia, Lipemia, Pancreatitis

Full Text:



Gursoy A, Kulaksizoglu M, Sahin M, Ertugrul DT, Ozer F, Tutuncu NB, et al. Severe hypertriglyceridemia-induced pancreatitis during pregnancy, J National Med Assoc. 2006;98(4):655-7.

Athyros VG, Giouleme OI, Nikolaidis NL, Vasiliadis TV, Bouloukos VI, Kontopoulos AG, et al. Long-term follow-up of patients with acute hypertriglyceridemia-induced pancreatitis. J Clin Gastroenterol. 2002;34(4):472-5.

Lykkesfeldt G, Bock JE, Pedersen FD, Meinertz H, Faergeman O. Excessive hypertriglyceridemia and pancreatitis in pregnancy. Association with deficiency of lipoprotein lipase. Acta Obstetricia et Gynecologica Scandinavica. 1981;60(1):79-82.

Ramin KD, Ramin SM, Richey SD, Cunningham FG. Acute pancreatitis in pregnancy. Am J Obstet Gynecol. 1995;173(1):187-91.

Alagözlü H, Cindoruk M, Karakan T, Ünal S. Heparin and insulin in the treatment of hypertriglyceridemia-induced severe acute pancreatitis. Digestive Diseases Sciences. 2006;51(5):931-3.

Routy JP, Smith GHR, Blank DW, Gilfix BM, Plasmapheresis in the treatment of an acute pancreatitis due to protease inhibitor-induced hypertriglyceridemia. J Clinical Apheresis. 2001;16(3):157-9.

Takaishi K, Miyoshi J, Matsumura T, Honda R, Ohba T, Katabuchi H. Hypertriglyceridemic acute pancreatitis during pregnancy: prevention with diet therapy and 𝜔-3 fatty acids in the following pregnancy. Nutrition. 2009;25(11-12):1094-7.

de Chalain TMB, Michell WL, Berger GMB, Hyperlipidemia, pregnancy and pancreatitis. Surg Gynecol Obstet. 1988;167(6):469-73.

Mizushfrna T, Ochi K, Matsumura N, Ichimura M, Ishibashi T, Tsuboi K, et al. Prevention of hyperlipidemic acute pancreatitis during pregnancy with medium-chain triglyceride nutritional support. Int J Pancreatol. 1998;23(3):187-92.

Altun D, Eren G, Cukurova Z, Herg¨unsel O, Yasar L. An alternative treatment in hypertriglyceridemia-induced acute pancreatitis in pregnancy: plasmapheresis. J Anaesthesiol Clin Pharmacol. 2012;28(2):252-4.

Cahalane AM, Smith MJ, Ryan J, Maguire D, Acute pancreatitis secondary to gestational hypertriglyceridaemia. Case Reports in Medicine. 2012:627890.

Henzen C, R¨ock M, Schnieper C, Heer K. Heparin and insulin in the treatment of acute hypertriglyceridaemia induced pancreatitis. Swiss Medical Weekly. 1999;129(35):1242-8.