DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20175249

Role of omega 3 fatty acids on pregnancy outcome

Sirisha Anne, Aruna Menon, Sameena Parikh

Abstract


Background: Maternal nutrition plays a crucial role on influencing fetal growth and birth outcome. Any nutritional insult during critical periods of gestation is known to influence fetal development and increases the risk for development of diseases in later life. Omega 3 and omega 6 fatty acids have been studied to effect fetal growth and development. The balance between these two fatty acids have a definite effect on fetal growth and duration of gestation. Dietary intake of omega 3 fatty acids is less as compared to omega 6 fatty acids due to varied dietary sources.

Methods: A study was conducted at a tertiary care hospital to study the pregnancy outcome in terms of neonatal birth weight and duration of gestation. A total of 200 patients were recruited into the study and divided into two groups by randomised alternative method. One group of 100 patients were supplemented with Omega 3 fatty acids and the other group was not supplemented. Both groups were followed till delivery and their duration of gestation and neonatal birth weight were studied and analysed.

Results: The study showed that 78.8% patients supplemented with omega 3 fatty acids achieved neonatal birth weight more than 2.5Kg compared to 50% of patients who were not supplemented. No significant difference on duration of gestation was found in both the groups.

Conclusions: Supplementation of Omega 3 fatty acids to patients in our study has shown to increase neonatal birth weight compared to patients who have not been supplemented, and did not show any significance in prolonging duration of gestation.


Keywords


Neonatal birth weight, Omega 3 fatty acids, Pre term labour

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References


Nordgren TM, Lyden E, Anderson-Berry A, Hanson C. Omega-3 fatty acid intake of pregnant women and women of childbearing age in the united states: potential for deficiency?. Nutrients. 2017 Feb 26;9(3):197.

Fereidooni B, Jenabi E. The use of omega 3 on pregnancy outcomes: a single-center study. J Pak Med Assoc. 2014 Dec 1;64(12):1363-5.

Innis S, Uauy R. Mechanisms of action of LCPUFA effects on infant growth and neurodevelopment: perinatal biochemistry and physiology of LCPUFA discussion. J Pediatr. 2003 Oct 31;143(4):96-109.

McCormick MC. The contribution of low birth weight to infant mortality and childhood morbidity. N Eng J Med. 1985 Jan 10;312(2):82-90.

Olsen S, So̸rensen TA, Secher N, Hansen H, Jensen B, Sommer S et al. Intake of marine fat, rich in (n-3)-polyunsaturated fatty acids, may increase birthweight by prolonging gestation. Lancet. 1986 Aug 16;328(8503):367-9.

Holman RT. The slow discovery of the importance of ω3 essential fatty acids in human health. J Nutr. 1998 Feb 1;128(2):427S-33S.

Decsi T, Koletzko B. Growth, fatty acid composition of plasma lipid classes, and plasma retinol and alpha-tocopherol concentrations in full-term infants fed formula enriched with omega-6 and omega-3 long-chain polyunsaturated fatty acids. Acta Paediatr. 1995;84(7):725-32.

Birch EE, Hoffman DR, Uauy R, Birch DG, Prestidge C. Visual acuity and the essentiality of docosahexaenoic acid and arachidonic acid in the diet of term infants. Pediatr Res. 1998 Aug 1;44(2):201-9.

Makrides M, Neumann MA, Simmer K, Gibson RA. Dietary long-chain polyunsaturated fatty acids do not influence growth of term infants: A randomized clinical trial. Pediatrics. 1999;104(3 Pt 1):468-75.

Dunstan JA, Mori TA, Barden A, Beilin LJ, Holt PG, Calder PC, et al. Effects of n-3 polyunsaturated fatty acid supplementation in pregnancy on maternal and fetal erythrocyte fatty composition. Eur J Clin Nutr. 2004;58(3):429-37.

Burdge G. Alpha-linolenic acid metabolism in men and women: nutritional and biological implications. Curren Opin Clin Nutr Metab Care. 2004 Mar;7(2):137-40.

Bell SJ, Bradley D, Forse RA, Bistrian BR. The new dietary fats in health and disease. J Am Diet Assoc. 1997 Mar;97(3):280-6.

Carlson SE, Rhodes PG, Ferguson MG. Docosahexaenoic acid status of preterm infants at birth and following feeding with human milk or formula. Am J Clin Nutr. 1986;44(6):798-804.

Anderson JW, Johnstone BM, Remley DT. Breast-feeding and cognitive development: A meta-analysis. Am J Clin Nutr .1999;70(4)

Dyerberg J, Bang HO, Walters BN, Walters T, Atallah A, Schinnar R et al. Pre-eclampsia and prostaglandins. The Lancet. 1985 Jun 1;325(8440):1267-8.