DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20175251

Comparative study to evaluate the prevalence of deranged lipid profile and oral glucose tolerance test in polycystic ovarian syndrome patients with normal females: a prospective observational study

Isha Rani Phutela, Basharat Hussain Pandit, Asia Ashraf, Sadia Ali Wani, Mehraj Ud Din

Abstract


Background: PCOS is a complex endocrine disorder characterized by menstrual dysfunction, anovulation, infertility and hyper androgenic symptoms with dyslipidaemia, cardiovascular diseases, and impaired glucose tolerance and type II diabetes mellitus. Multiple risk factors are involved in the pathogenesis of PCOS.

Methods: A comparative evaluation of deranged lipid profile and OGTT in PCOS patients with normal females was done in patients with age group of 15 to 30 years. The Rotterdam criteria for PCOS was used for selection of the participants prospectively and a detailed history regarding period of amenorrhea, menstrual cycles, obstetric history, any past history of medical disorder were taken followed by general physical, systemic and obstetric examination. All the patients underwent Ultrasound examination, OGTT and lipid profile, prolactin, 17-OH progesterone and testosterone level.

Results: A significant association of PCOS with deranged lipid profile and blood glucose tolerance and obesity was observed. Patients with PCOS had higher prevalence of oligomenorrhoea, infertility, hirsutism and acne. Furthermore, a statistically significant trend was seen where signs and symptoms like infertility, hirsutism and acne, deranged OGTT and dyslipidaemia were more frequently associated with increased BMI, sedentary life style intake of high calorie diets.

Conclusions: An association between obesity, sedentary lifestyle, and dietary factors with PCOS was observed which can be modified to improve the health condition of the women with PCOS.


Keywords


Dyslipidemia, Impaired glucose tolerance, Infertility, Metabolic syndrome, PCOS

Full Text:

PDF

References


Pasquali R, Stener-Victorin E, Yildiz BO, Duleba AJ, Hoeger K, Mason H, et al. Forum: research in polycystic ovary syndrome today and tomorrow. Clin Endocrinol (Oxf). 2011;74:424-33.

Balen A, Conway G, Kaltsas G. Polycystic ovary syndrome: the spectrum of the disorder in 1741 patients. Hum Reprod. 1995;10:2107-11.

Sirmans SM, Pate KA. Epidemiology, diagnosis, and management of polycystic ovary syndrome. Clin Epidemiol. 2013;6:1-13.

Nidhi C, Venkatram P, Raghuram N, Amritanshu R. Prevalence of polycystic ovarian syndrome in Indian adolescents. J Pediatr Adolescent Gynecol. 2001;24:223-7.

Sozen I, Arici A. Hyperinsulinism and its interaction with hyperandrogenism in polycystic ovary syndrome. Obstet Gynecol Surv. 2000;55:321-8.

Farquhar CM, Birdsall M, Manning P, Mitchell JM, France JT. The prevalence of polycystic ovaries on ultrasound scanning in a population of randomly selected women. Aust NZ Obstet Gynaecol. 1994;34:67-72.

Ramanand SJ, Ghongane BB, Ramanand JB, Patwardhan MH, Ghanghas RR, Jain SS. Clinical characteristics of polycystic ovary syndrome in Indian women. Indian J Endocrinol Metab. 2013;17:138-45.

Lord J, Thomas R, Fox B, Acharya U, Wilkin T. The central issue? visceral fat is a good marker of insulin resistance and metabolic disturbances in women with polycystic ovary syndrome. BJOG. 2006;113:1203-9.

Ovalle F, Azziz R. Insulin resistance, polycystic ovary syndrome, and type 2 diabetes mellitus. Fertil Steril. 2002;77(6):1095-105.

Pelusi B, Gambineri A, Pasquali R. Type 2 diabetes and the polycystic ovary syndrome. Minerva Ginecol. 2004;56(1):41-51.

Kalra A, Nair S, Rai L. Association of obesity and insulin resistance with dyslipidemia in Indian women with polycystic ovarian syndrome. Indian J Med Sci. 2006;60:447-53.

Hart R. PCOS and infertility. Panminerva Med. 2008;50:305-14.

Yuan C, Liu X, Mao Y, Diao F, Cui Y, Liu J. Polycystic ovary syndrome patients with high BMI tend to have functional disorders of androgen excess: a prospective study. J Biomed Res. 2016;30(3):197-202.

Akshaya S, Bhattacharya R. Comparative study of metabolic profile of women presenting with polycystic ovary syndrome in relation to body mass index. Int J Reprod Contracept Obstet Gynecol 2016;5:2561-5.

Coles N, Bremer K, Kives S, Zhao X, Hamilton J. Utility of the oral glucose tolerance test to assess glucose abnormalities in adolescents with polycystic ovary syndrome. J Pediatr Adolesc Gynecol. 2016;29(1):48-52.

Lekshmiammal P, Krishnadas S. Hyperinsulinemia in polycystic ovary syndrome. J Med Sci Clin Res. 2017;5(5):21286-92.

Yousuf R, Khan M, Kounsar Z, Ahangar S, Lone WA. Polycystic ovarian syndrome: clinical correlation with biochemical status. Surg Sci. 2012;3:245-8.

Sedighi S, Akbari AAS, Afrakhteh M, Esteki T, Majd AH, Mahmoodi Z. Comparison of lifestyle in women with polycystic ovary syndrome and healthy women. Glob J Health Sci. 2015;7:228-34.

Traub ML. Assessing and treating insulin resistance in women with polycystic ovarian syndrome. World J Diabetes. 2011;2:33-40.

Çelik E, Türkçüoğlu I, Ata B, Karaer A, Kırıcı P, Eraslan S, et al. Metabolic and carbohydrate characteristics of different phenotypes of polycystic ovary syndrome. J Turkish German Gynecol Assoc. 2016;17(4):201-8.

Saxena P, Prakash A, Nigam A, Mishra A. PCOS: is obesity a sine qua non? a clinical, hormonal and metabolic assessment in relation to BMI. Indian J Endocrinol Metab. 2012;16(6):996-9.

Shoaib OM, Mustafa SM, Nourein IH. Serum lipid profile of polycystic ovary syndrome in Sudanese women. Int J Med Sci Pub Health. 2015;4(11):1605-10.

Lath R, Shendye R, Jibhkate A. Insulin resistance and lipid profle in polycystic ovary syndrome. Asian J Biomed Pharm Sci. 2015;5(48):30-5.

Ahmadi A, Akbarzadeh M, Mohammadi F, Akbari M, Jafari B, Tolide-Ie HR. Anthropometric characteristics and dietary pattern of women with polycystic ovary syndrome. Indian J Endocrinol Metab. 2013;17(4):672-6.