Fetal and maternal outcome following expectant management of severe pre-eclampsia remote from term
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20175253Keywords:
Early onset severe preeclampsia, Expectant management, Maternal morbidity, Perinatal outcomeAbstract
Background: Expectant management of severe preeclampsia, remote from term is often a difficult decision. Maternal and foetal complications may occur while trying to achieve a more favourable perinatal outcome. We wanted to find out the foetal and maternal outcomes of expectant management in these women.
Methods: A prospective cohort study was conducted at Government Medical College, Thrissur, India between May 2013 and April 2015. Women with severe preeclampsia remote from term, who were admitted, managed expectantly and delivered in our hospital during the study period, were recruited. The study subjects were grouped into: Group A (between 28 weeks and 31 weeks 6 days) and Group B (between 32 weeks and 33 weeks 6 days). A structured proforma was used to collect demographic and clinical details. The maternal and foetal outcomes were noted.
Results: There were 4786 deliveries during the study period. Among them 76 (1.58% of total deliveries) women with severe preeclampsia between 28 weeks and 33-week 6 days gestation on expectant management were included in the study. The mean duration of expectant management was 7.92 days in group A (27 women) and 6.67 days in group B (49 women). Most women required termination of pregnancy for foetal distress (36.8%). HELLP syndrome and imminent eclampsia were the maternal complications that occurred. Perinatal loss was significantly more in Group A when compared to Group B.
Conclusions: Expectant management of women with severe preeclampsia remote from term, especially between 32weeks and 33weeks 6 days, with antenatal corticosteroids and close monitoring, seems a reasonable option in developing countries.
Metrics
References
Ciantar E, Walker JJ. Pre-eclampsia, severe pre-eclampsia and hemolysis. Elevated liver enzymes and low platelets syndrome: what is new?. Womens Health. 2011;7:555-69.
Lisonkova S, Sabr Y, Mayer C, Young C, Skoll A, Joseph KS. Maternal morbidity associated with early-onset and late-onset preeclampsia. Obstet Gynecol. 2014;124:771-81.
Churchill D, Duley L, Thornton JG, Jones L. Interventionist versus expectant care for severe pre-eclampsia between 24 and 34 weeks’ gestation. The Cochrane Database of Systematic Reviews. 2013;7:CD003106.
Lindheimer MD, Taler SJ, Cunningham FG: Hypertension in pregnancy. J Am Soc Hypertens 2:484:2008b.
Gracia VP, Tejada RO, Miñaca CAC, Tellez G, Chon VY, Herrarte E, et al. Expectant management of severe preeclampsia remote from term: the MEXPRE Latin study, a randomized, multicenter clinical trial. Am J Obstet Gynecol 2013;209:425.e1-8.
Sibai BM, Mercer BM, Schiff E, Friedman SA. Aggressive versus expectant management of severe preeclampsia at 28 to 32 weeks’ gestation: a randomized controlled trial. Am J Obstet Gynaecol. 1994;171:818-22.
Sibai BM, Barton JR. Expectant management of severe preeclampsia remote from term: patient selection, treatment, and delivery indications. Am J Obstet Gynaecol. 2007;196:514.
Odendaal HJ, Pattinson RC, Bam R, Grove D, Kotze TJ. Aggressive or expectant management for patients with severe preeclampsia between 28-34 weeks’ gestation: a randomized controlled trial. Obstet Gynaecol. 1990;76:1070-5.
Sibai BM, Taslimi M, Abdella TN, Brooks TF, Spinnato JA, Anderson GD. Maternal and perinatal outcome of conservative management of severe preeclampsia in mid-trimester. Am J Obstet Gynaecol. 1985;152:32-7.
Oettle C, Hall D, Roux A, Grove D. Early onset pre-eclampsia: expectant management in a secondary hospital in close association with a tertiary care institution. BJOG. 2005;112;84-8.
Marozio L, Gibbone E, Polarolo G, Carbonara C, Berchialla P. Expectant management of severe preeclampsia remote from term: a hospital-based survey. Ann Reprod Med Treat. 206;1(1):1005.