Study of role of Magnesium sulfate in prevention of eclampsia

Srinivas N. Gadappa; Pratibha Dixit

doi:10.18203/2320-1770.ijrcog20175268

Authors

Srinivas N. Gadappa Department of Obstetrics and Gynecology, Government Medical College Aurangabad, Maharashtra, India
Pratibha Dixit Department of Obstetrics and Gynecology, Government Medical College Aurangabad, Maharashtra, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20175268

Keywords:

Anticonvulsant, Eclampsia, Hypertensive disorders of pregnancy

Abstract

Background: Hypertensive disorders of pregnancy have a clinical spectrum ranging from non-severe to severe preeclampsia and then potentially to eclampsia. Magnesium sulfate is drug of choice for women with eclampsia and now adapted for prophylaxis of seizures in women with preeclampsia.

Methods: It is randomized clinical trial, including 876 patients with preeclampsia fulfilling inclusion criteria. Patients with severe preeclampsia received anticonvulsant prophylaxis with magnesium sulfate. Patients with non-severe preeclampsia were randomized in two groups study group and control group. Patients in study group had received anticonvulsant prophylaxis with magnesium sulfate. The data obtained was analyzed with respect to maternal and perinatal outcome, severity of disease progression and adverse reactions of magnesium sulphate in each group.

Results: In this study statistically, significant difference was seen with respect to severity of disease progression and incidence of eclampsia among study and control group.

Conclusions: Administration of Magnesium sulfate in patients with non-severe preeclampsia does not affect the progress of labour or perinatal outcome, on contrary it improves maternal outcome by reducing incidence of eclampsia and progression of disease, without significant side effect of drug.

Metrics

Metrics Loading ...

Author Biography

Pratibha Dixit, Department of Obstetrics and Gynecology, Government Medical College Aurangabad, Maharashtra, India

References

Sardesai S, Maira S, Patil A, Patil U. Low dose magnesium sulfate therapy for eclampsia and imminent eclampsia; Regime tailored for Indian women. J Obstet Gynecol India. 2003;53(6):540-6.

Altman D, Carroli G, Duley L, Farrell B, Moodley J, Neilson J, et al. Do women with preeclampsia and their babies benefit from magnesium sulfate? The Magpie trial: a randomized placebo trial. Lancet 2002;359:1877-90.

Cotton DB, Janusz CA, Berman RF. Anticonvulsant effect of magnesium sulfate on hippocampal seizures: therapeutic implications in preeclampsia-eclampsia. Am J Obstet Gynaecol. 1992;166:1127.

Atkinson MW, Guinn D, Owen J, Hauth JC. Does magnesium sulfate the length of labour induction in women with pregnancy associated hypertension? Am J Obstet Gynaecol. 1995:173;1219-22.

Moodley J, Moodley VV. Prophylactic anticonvulsant therapy in hypertensive crises of pregnancy: the need for a large randomized trial. 1994;13:245-52.

Dayicioglu V, Sahino Z, Kola E, Kucukbas M. The use of standard dose of magnesium sulfate in prophylaxis of eclamptic seizures: Do body mass index alterations have any effect on success?. Hypertension in Pregnancy. 2003;22(3):257-65.

Livingston JC, Livingston LW, Ramsey R, Mabie BC, Sibai BM. Magnesium sulfate in women with mild preeclampsia: a randomized controlled trial. J Obst Gynecol. 2003;101:217-20.

Red LL, Ross A, Kloss M, Paull J, Markman L. The management of severe preeclampsia with intravenous magnesium sulphate, hydralazine and central venous catheterization. Au N Z J Obstet Gynaecol. 1987;27(2):102-5.

Girard B, Beucher G, Muris C, Simonet T, Dreyfus M. Magnesium sulfate and severe preeclampsia: its use in current practice. J Gynecol Obstet Biol Reprod. 2005;34:17-22.

Singh J, O’Donovan M, Coultersmith SD, Geary M. An audit of the use of magnesium sulphate in severe preeclampsia and eclampsia. J Obstet Gynecol 2005;25(1):15-7.

Alexander JM, McIntire DD, Leveno KJ, Cunningham FG. Selective magnesium sulfate prophylaxis for the prevention of eclampsia in women gestational hypertension. Obstet Gynecol. 2006;108(4):826-32.

Szal ES, Croughan-Minihane MS, Kilpatrick SJ. Effects of magnesium prophylaxis and preeclampsia on the duration of labor. Am J Obstet Gynecol. 1999;180:1475-9.