A rare case report: pregnancy with pancytopenia
Keywords:Normoblastic erythroid hyperplasia, Pancytopenia, Pregnancy
Pancytopenia is reduction in all the three major cellular elements of blood, hence it is the simultaneous presence of anaemia, leukopenia and thrombocytopenia. Here we present a case of a 28-year-old female, G4P3L1D2 with previous LSCS with 30 weeks gestation with pancytopenia managed with steroids and transfusions.
Metikurke SH, Rashmi K, Bhavika R. Correlation of bone marrow aspirate, biopsies and touch imprint findings in pancytopenia. J Hematol. 2013;2:8-13.
Khodke K, Marwah S, Buxi G, Yadav RB, Chaturvedi NK. Bone marrow examination in cases of pancytopenia. J Indian Academy Clin Med. 2001;2:55-9.
Varma N, Dash S. A reappraisal of underlying pathology in adult patients presenting with pancytopenia. Trop Geogr Med. 1992;44:322-7.
Deka D, Malhotra N, Sinha A. Pregnancy associated aplastic anemia: maternal and fetal outcome. J Obstet Gynaecol Res. 2003;29:67-72.
Deka D, Banerjee N, Roy K. Aplastic anemia during pregnancy: variable clinical course and outcome. Eur J Obstet Gynecol Reprod Biol. 2001;94:152-4.
Oosterkamp HM, Brand A, Kluin-Nelemans JC, Vandenbroucke JP. Pregnancy and severe aplastic anaemia: causal relation or coincidence?. Br J Haematol. 1998;103:315-6.
Yang ZS, Mei-Ying L, Mi W, Xiao-Hui Z. Pregnancy and myelodysplastic syndrome: An analysis of the clinical characteristics, maternal and fetal outcomes. J Maternal-Fetal Neonatal Med. 2015;28(18):2155-9.
Shimamura A, Alter BP. Inherited aplastic anemia syndrome. In: Greer JP, Foerster J, Rodgers GM, Paraskevas F, Gladet B, Arber DA, editors. Wintrobe's clinical hematology. Philadelphia: Lippincott Williams and Wilkins; 2008:1173-1261.
Jha A, Sayami G, Adhikari RC, Panta AD, Jha R. Bone marrow examination in cases of pancytopenia. J Nepal Med Assoc. 2008;47:12-7.
Imbert M, Scoazec JY, Mary JY, Jouzult H, Rochant H, Sultan C. Adult patients presenting with pancytopenia: a reappraisal of underlying pathology and diagnostic procedures in 213 cases. Hematol Pathol. 1989;3:159-67.
Bone marrow examination: indication, technique. In: Anesoft, Foucar K, editors. Bone marrow pathology. Hong Kong: American Society Clinical Pathology; 2001:30-47.
Nanda A, Basu S, Marwaha N. Bone marrow trephine biopsy as an adjunct to bone marrow aspiration. J Assoc Physicians India. 2002;50:893-5.
Kumar DB, Raghupati AR. Clinicohematological analysis of pancytopenia. Basic Applied Pathol. 2012;5:19-21.
Liu Y, Du L, Osato M. The zebrafish udu gene encodes a novel nuclear factor and is essential for primitive erythroid cell development. Blood. 2008;110(1):3331-42.