DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20175136

Evaluation of intravenous iron sucrose therapy for management of moderate to severe anaemia in pregnancy

Pankajkumar B. Nimbalkar, Jaldhara N. Patel, Nilesh Thakor

Abstract


Background: Iron deficiency anaemia (IDA) is the most common nutritional deficiency in pregnancy and major contributory factor to maternal morbidity and mortality. Objective of present study was to evaluate the response and effectof parenteral iron sucrose complex therapy in iron deficiency anemia in pregnancy.

Methods: A prospective observational study was conducted at GMERS Medical College, Dharpur-Patan over a period extending from September 2014 to August 2017. A total of 150 Antenatal women, between 26-32 weeks of pregnancy with hemoglobin between 5-9 gm% were selected for study by purposive sampling. They were given intravenous iron sucrose complex in a dose of 200 mg (2 ampules of 5 ml each) in 100 ml normal saline over a period of 15-20 minutes, on alternate day. Repeat CBC was done after a period of 6 weeks.

Results: Age range of the patients was 20 to 34 years. Out of total 150 women, 72 women (48%) were in age group of 20-24 years. 64.6% women had 27-29 weeks of pregnancy. 58 (38.6%) women had <8 gm% of Hb before treatment and 108 (72%) women achieved Hb of 10 gm% after treatment. The mean haemoglobin raised from 7.9±0.92 gm% to 10.3±0.83 gm% (P<0.001) after six weeks of therapy. There was significant rise in MCV levels (from 67.7±5.1 fl to 78.9±6.4fl) (P<0.001). Major side effects or anaphylactic reactions were occurred in none of the women during study period. 93.3% of patients, treated for anemia were delivered at full term, either vaginally (67.3%) or by LSCS (26%). Most of the delivered babies (80%), had birth weight of more than 2.5 kgs.

Conclusions: Parentral iron therapy was effective in increasing haemoglobin and other haematological parameters in pregnant women with moderate to severe anaemia.


Keywords


Anaemia, Iron deficiency, Iron sucrose complex, MCV, Parentral iron therapy

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References


Breymann C. Iron deficiency and anemia in pregnancy: modern aspects of diagnosis and therapy. Blood Cells Mol Dis. 2002;29:506-16.

Khan MM. Effects of maternal anemia on fetal parameters. J Ayub Med Coll Abbottabad. 2001;13:38-41.

Thakor N, Bhagora S, Asari U, Kharadi A, pandor J, prajapati D. Effect of intravenous iron sucrose therapy for moderate-to-severe anemia in pregnancy: a longitudinal study. Int J Med Sci Public Health. 2015;4:11-14.

International institute for population sciences (IIPS) and macro International. 2016. National family health survey (NFHS-4), India, 2015-16: India. Mumbai: IIPS. Available at http://rchiips.org/NFHS/pdf/NFHS4/India.pdf. Accessed on 15 October 2017

International institute for population sciences (IIPS) and macro International. 2016. National family health survey (NFHS-4), India, 2015-16: Gujarat. Mumbai: IIPS Available at http://rchiips.org/NFHS/pdf/NFHS4/GJ_FactSheet.pdf Accessed on 15 October 2015

Saeed GA. A 52-year-old lady presenting with pregnancy and anemia. Pak Armed Forces Med J. 2002;52:223-4.

Ahmed K, Sadiq I, Yousuf AW. Injectable iron therapy: intramuscular Vs intravenous therapy. Biomedica. 2000;16:44-7.

Wali A, Mushtaq A, Nilofer. Comparative study: efficacy, safety and compliance of intravenous iron sucrose and intramuscular iron sorbitol in iron deficiency anemia of pregnancy. J Pak Med Assoc. 2002;52:392-5.

Giannoulis C, Daniilidis A, Tantanasis T, Dinas K, Tzafettas J. Intravenous administation of iron sucrose for treating anemia in postpartum women. Hippokratia. 2009;13:38-40.

Kriplani A, Mahey R. Intravenous iron sucrose therapy for moderate to severe anaemia in pregnancy, Indian J Med Res. 2013;138(1):78-82.

Patel S, Goyal A, Shrivastava A, Verma R. Safety and efficacy of parenteral iron sucrose complex therapy in iron deficiency anemia in antenatal and postnatal women. Int J Med Sci Public Health. 2013;2:360-3.

Neeru S, Nair NS, Rai L. Iron sucrose versus oral iron therapy in pregnancy anemia. Indian J Community Med. 2012;37:214-8.

Al-Memon AK, al-Meshari A, al-Nuaim L, Saddique A, Abotalib Z, Khashogji T et al. Intravenous iron sucrose complex in the treatment of iron deficiency anemia during pregnancy. Eur J Obstet Gynec. 1996 Nov, 69(2);121-4.

KV K, Guru PB, Srinivasa RK, Manavalan R, Manna PK, Mohanta GP et al. Study of effect of intravenous iron sucrose in the treatment of puerperal anemia. Indian J Pharm Pract. 2010 Oct;3(4):14.

Raja K, Janjua NB, Khokhar N. Intravenous iron sucrose therapy in iron deficiency anemia in pregnancy. J Pak Med Assoc. 2003;28(2).

Halimi S, Halimi SM, Shoaib M. Oral versus parenteral iron therapy for correction of iron deficiency anaemia in pregnancy. Gomal J Med Sci. 2010 Dec 31;9(1):3-5.