A comparative study of maternal outcome between low dose and standard dose magnesium sulphate as regimen for the treatment of eclampsia in a tertiary centre

Minakshi Mohanty, Sasmita Behuria, Rohani Nayak


Background: Eclampsia is an obstetric emergency complicating the maternal outcome in all developing countries. Various regimen of magnesium sulphate have been tried to treat the condition with varied results. A few studies have been done to compare between various types of regimen in this part of India. Magnesium sulphate is a double edged sword. Aim of the study was to compare the maternal morbidity and mortality after administering two different regimen of magnesium sulphate in eclampsia patients in a tertiary care hospital in Odisha.

Methods: This is a randomized prospective study conducted at the Labour room, Dept of O and GSCB Medical College, Cuttack, Odisha over a period of 18 months (January 2015 to June 2016). 228 eclampsia patients were randomly selected out of which 114 were administered low dose (Dhaka) regimen and the other 114 subjects were given high dose (Pritchard) regimen. The findings were analysed using SPSS version 21.

Results: In low dose regimen group convulsion was controlled in 96% of eclampsia patients and in only few cases recurrence of seizure occurred and was shifted to standard dose regimen.

Conclusions: The toxicity profile also seems to be less so low dose regimen (Dhaka) can be adopted with less toxicity in peripheral hospitals with low resource setting.


Eclampsia, Low dose, Magnesium sulphate

Full Text: