Thyroid abnormality in abnormal uterine bleeding: an observational study from Medical College in Western UP, India
Keywords:Abnormal uterine bleeding, Hyperthyroidism, Hypothyroidism
Background: Abnormal Uterine Bleeding (AUB) is one of the commonest gynecological complain in reproductive age group. Menstrual abnormalities are commonly seen when there is any alteration in thyroid function. Objective of present study was to investigate the prevalence of AUB and to determine the menstrual pattern in cases with thyroid dysfunction.
Methods: The present cross sectional observational study was conducted Teerthankar Mahaveer Medical College and Research Center Moradabad. Total 400 cases presenting with AUB were included in the study. Routine blood test, ultrasonography and thyroid function tests were done in these cases.
Results: Among all the cases presenting with menstrual abnormalities 26% had hypothyroidism and 9% have hyperthyroidism and rest had euthyroid status. Menorrhagia (45.2%) and polymenorrhoea (37.5%) were commonest menstrual abnormality seen in cases with hypothyroidism. Most cases with hyperthyroidism presented with hypomenorrhoea (27.8%).
Conclusions: Thyroid function abnormality is common in cases presenting with AUB and it gets relieved in correcting hormonal imbalance.
Abers JR, Hull SK, Wesley RM. AUB. Am Fam Phy. 2004;68(8):1915-34.
Poppe K, Glinoer D. Thyroid autoimmunity and hypothyroidism before and during pregnancy.Human Reprod Update. 2003;9:149-161.
Thomas R, Reid RL. Thyroid diseases and reproductive dysfunction. Obstet Gynecol. 1987;70:789-98.
Gowri M, Radhika BH, Harshini V, Ramaiaha R. Role of thyroid function tests in women with abnormal uterine bleeding. Int J Reprod Contracept Obstet Gynecol. 2014;3(1):54-7.
Kochupillai N. Clinical endocrinology in India. Curr Sci. 2000;79:1061-7.
Hollowell JG, Stachling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA et al. Serum TSH, T4, and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab. 2002;87(2):489-99.
Cappole AR, ladenson PW. Hypothyroidism and atherosclerosis. J Clin Endocrinol Metab. 2003;88:2438-44.
Byna P, Siddula S, Kolli S, Shaik MV. Thyroid abnormality in perimenopausal women with abnormal uterine bleeding. Int J Res Med Sci. 2015;3:3250-3.
Pilli GS, Sethi B, Dhaded AV, Mathur PR. Dysfun uterine bleeding. J Obstet Gynaecol Ind. 2001;52(3):87-9.
Sharma N, Sharma A. Thyroid profile in menstrual disorders. JK Sci. 2012;14(1):14-17.
Rani AS, Rekaha B, Reddy GA. Study of hypothyroidism in women with abnormal uterine bleeding. IOSR-JDMS. 2016;15(4):12-18.
Pahwa S, Shailja G, Jasmine K. Thyroid dysfunction in DUB. J Adv Res Bio Sci. 2013;5(1):78-839.
Padmahela K, Thomas V, Lawanya KM, Kiranmai D. Thyroid disorders in DUB among reproductive age group women- a cross sectional study in a tertiary care hospital in Andhra Pradesh India. Int J Med Pharma Sci. 2013;4(1):41-4610.
Kaur T, Asuja V, Sharma S. Thyroid dysfunction in AUB. Web Med Central Obstet Gynecol. 2011;2(9):1-7.