Study of incidence of antiphospholipid antibody syndrome and low vitamin D levels as an etiological factor in recurrent pregnanc loss and their correlation


  • Rahul S. Upadhyay Department of Obstetrics and Gynaecology, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, Maharashtra, India
  • Michelle N. Fonseca Department of Obstetrics and Gynaecology, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, Maharashtra, India



Recurrent pregnancy loss (RPL), Antiphospholipid antibody (APLA), Vitamin D


Background: Recurrent pregnancy loss is a heterogeneous reproductive problem, with multiple etiologies. Objective of this study was to study the incidence of APLA syndrome and low vitamin d levels in RPL and correlation between APLA syndrome and low vitamin D levels.

Methods: This was an observational study conducted on 110 women seen in outpatient department/inpatient department of our institution from 1st August 2015 to 31st July 2016 who were known cases of RPL who fitted our inclusion and exclusion criteria.

Results: It was found that majority of the RPL patients were in the age group of 30-34 years (42.72%) and they contributed to 43% of the abortions. 77.4% abortions occurred in the gestational age of 6-8 weeks. 21.81% patients were APLA positive. 23.63% patients had  low vitamin D levels. Out of the 21.81% patients who were APLA positive (50%) also had a low vitamin D level which was found to be statistically significant.

Conclusions: There appears to be some correlation between APLA syndrome and low vitamin D levels, so both have to be treated simultaneously. Properly investigating women for APLA syndrome and vitamin D deficiency would select a treatable group of women with RPL.


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Original Research Articles