Retrospective study of clinico-pathological features of ovarian tumors


  • Sachin G. Vedpathak Department of Obstetrics and Gynecology, MIMER Medical College, Talegaon Dabhade, Pune, Maharashtra, India
  • Vaishali R. Korde Nayak Department of Obstetrics and Gynecology, MIMER Medical College, Talegaon Dabhade, Pune, Maharashtra, India



CA 125, Clinical features, Histopathological diagnosis, Risk factors, Ovarian tumors


Background: Ovarian masses are a frequent clinical diagnosis in general Gynecology. The aim of the present study was to assess risk factors, clinical features, CA 125 levels, histopathological diagnosis of the patients of all ovarian tumors that underwent surgical management between August 2013 to August 2017.

Methods: This was the retrospective study conducted in the department of Obstetrics and Gynecology in MIMER Medical College. We studied 50 patients those who underwent surgical management. Most of the patients 56% were in the reproductive age group, 28% patients were in the perimenopausal age group, 14% were in the postmenopausal age group. 82% patients were parous.

Results: Pain abdomen was most common symptom in 50% patients. Bilaterality of the tumor was common in malignant tumors. CA 125 was found to be increased more in malignant tumors. Most common co morbid condition was hypertension found in 12% patients. Most common ovarian tumor found was serous cystadenoma 34% and most common malignant tumors were serous cystadenoma carcinoma 16%.

Conclusions: Out of all operated patients 11 (22%) were malignant, 37 (74%) were benign and 2 (%) were borderline tumors. Out of all malignant tumors 8 (72%) were serous cysadenocarcinoma. It is difficult to always differentiate between malignant and benign tumors clinically. Analysis of risk factors and protective factors, thorough abdomino-pelvicbimanual examination, certain features on radiological imaging, presence of ascites and bilaterality, CA125 levels, helps increasing the accuracy of the diagnosis.


Berek JS, Longacre TA, Friedlander M. Ovarian, fallopian tube and peritoneal cancer: In Berek and Novaks Gynecology, 15th ed. Philadelphia. PA: Lippincott Williams and Wikins;2015:1350-1416.

Yogambal M. Arunalatha P, Chandramouleeswari K, Palaniappan V. Ovarian tumors-incidence and distribution in a tertiary referral centre in south India. IOSR J Dent Med Sci. 2014;13(2):74-80.

Bhasin SK, Vijaykumar, Rajkumar. Giant ovarian cyst: a case report. JK Sci. 2014;16(3).

Kumar P. Malhotra Ni Jeffcoates. Principles of Gynaecology. Jaypee Brothers Medical Publishers (P) Ltd; 7th edition; 2008.

Scully RE, Young RH, Clement PB, In: Scully RE, Young RH, Clement PB, eds. Atlas of tumor pathology of the ovary, maldeveloped gonads, fallopian tube and broad ligament. 3rd edition. Fasciele 23. Armed Forces Institute of Pathology. Washington DC; 1998:27-50.

Ruchikagarg. A clinicopathological study of malignant ovarian tumors in India. J South Asian Federation of Menopause Societies. 2014;2(1):9-11.

Purdie DM, Bain CJ, Siskind V, Webb PM, Green AC. Ovulation and the risk of epithelial ovarian cancer. Int J Cancer. 2003;104(2):228-32.

Rashid S, Sarwar G, Ali A. clinicopathological study of ovarian cancer. Department of radiotherapy and oncology. Sir Gangaram hospital and Mayo Hospital Lahore. J Park Med Arroe. 1998;36:117-25.

Hassan S. Abduljabbar. Review of 244 cases of ovarian cysts. Saudi Med J. 2015;36(7):834-8.

Markman M. Optimizing primary chemotherapy in ovarian cancer. Hemtol Oncol Clin North Am. 2003;17:957-68.

Bast RC Jr, Klug TL, St John E, Jenison E, Nilloff JM, Lazarus H, et al. A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. N Engl J Med. 1983;309:883-7.

Gangaraju S, Sarella LK, Chaveli L, Gurugubelli S. Scenario of ovarian mass lesions at a teaching hospital in Andhra Pradesh, India. IJRCOG. 2017;4(4):982-9.






Original Research Articles