Obstetric and neonatal outcome in women with a history of recurrent miscarriage at tertiary care hospital, Karnataka: a retrospective cross-sectional study

Chintan Upadhyay, Nisha Upadhyay


Background: When clinical pregnancy is established, the risk of spontaneous pregnancy loss is ~12-14%, and therefore the incidence of Recurrent Pregnancy Loss (RPL) by chance alone would be in the order of 0.35%. It occurs in 0.5-3% of women. The objective of this study was to evaluate the obstetric outcome in pregnancies with history of one or more abortions.

Methods: It is a retrospective cross-sectional study done at Obstetrics and Gynecology Department, Dr. B. R. Ambedkar Medical College and Hospital, Bangalore. Record review of cases was done from January 2005 to December 2009. Inclusion criteria were pregnancies with history of previous abortions.

Results: There were 400 cases with previous history of abortions. There were 266 (66.4%) booked cases while 134 (33.5%) were unbooked cases. 272 (68.0%) patients crossed viable period of pregnancy (more than 28 weeks). Around 56 (14.0%) cases had repeat abortions, 276 (69.0%) cases underwent vaginal delivery and 124 (31.0%) underwent cesarean section. Almost 91 (22.8%) of Babies were low birth weight while others were above 2.5 kg. There were 52 (13.0%) preterm babies and 28 (7.0%) Intrauterine demise of fetuses.

Conclusions: Patients with previous history of abortions are at increased risk of adverse maternal and perinatal outcome.


IUD, LBW, Perinatal outcome, Recurrent miscarriage

Full Text:



Bricker L. Types of pregnancy loss in recurrent miscarriage. Human Reprod. 2002;17(5),1345-50.

Policy guidance for health system: WHO, 2nd edition; 2012;1:17.

Wilcox AJ, Weinberg CR, O’Connor JF, Baird DD, Schlatterer JP, Canfield RE, et al. Incidence of early loss of pregnancy. N Engl J Med. 1988;319:189-94.

Miller JF, Williamson E, Glue J, Gordon YB, Grudzinskas JG, Sykes A. Fetal loss after implantation: a prospective study. Lancet. 1980;2:554-6.

Edmonds DK, Lindsay KS, Miller JF, Williamson E, Woods PJ. Early embryonic mortality in women. Fertil Steril. 1982;38:447-53.

Daya S. Evaluation and management of recurrent spontaneous abortion. Curr Opin Obstet Gynecol. 1993;8:188-92.

Tulppala M, Palosuo T, Ramsay T. A prospective study of 63 couples with a history or recurrent spontaneous abortion: contributing factors and outcome of subsequent pregnancies. Hum Reprod. 1993;8:764-70.

Katz YL, Kuller JA. Recurrent miscarriage. Am J Perinatol. 1994;11:386-97.

Quenby SM, Farquharson RG. Predicting recurring miscarriage: what is important? Obstet Gynecol. 1993;82:132-8.

Clifford K, Rae R, Regan L. Future pregnancy outcome in unexplained recurrent first trimester miscarriage. Hum Reprod. 1997;12:387-9.

Brigham SA, Conlon C, Farquharson RG. A longitudinal study of pregnancy outcome following idiopathic recurrent miscarriage. Hum Reprod. 1999;14(11):2868-71.

Annapurna P, Devi B, Devi BK. Pregnancy outcome following abortion. J of Evidence Based Med and Healthcare. 2015;2(41):6992-7002.

Zhou W, Sorensen HT, Olsena J. Induced abortion and low birthweight in the following pregnancy. Int J of Epidemiol. 2000;29:100-6.

Moreau C, Kaminski M, Ancel PY, Bouyer J, Escande B, Thiriez G, et al. Previous induced abortions and the risk of very preterm delivery: results of the EPIPAGE study. BJOG. 2005;112:430-7.

Basso O, Oslen J, Christensen K. Risk of preterm delivery, low birthweight and growth retardation following spontaneous abortion: a registry based study in Denmark. Int J Epidemiol. 1998;27:642.

Kashanian M, Akbarian AR, Baradaran H, Shabandoust SH. Pregnancy outcome following a previous spontaneous abortion (miscarriage). Gynecol Obstet Invest. 2006;61:167-70.

Jivraj S, Anstie B, Cheong YC, Fairlie FM, Laird SM, Li TC. Obstetric and neonatal outcome in women with a history of recurrent miscarriage: a cohort study. oxford journals. 2000;16(1):102 – 106.

Bhattacharya S, Townend J, Shetty A, Campbell D, Bhattacharya S. Does miscarriage in an initial pregnancy lead to adverse obstetric and perinatal outcomes in the next continuing pregnancy?. BJOG 2008;115(13):1623-9.