Spontaneous pregnancy after prepubertal haematopoietic cell transplantation

Eek Chaw Tan, Hemashree Rajesh


Spontaneous pregnancy after haematopoietic cell transplantation (HCT) is rare due to an increase incidence of premature ovarian failure resulting from pre-transplantation conditioning regimes. Increased number of long term survival of HCT patients has brought forth their fertility into focus. In this article, we reported a 34 years old woman who underwent HCT at prepubertal age and had a spontaneous pregnancy. In addition, we reviewed literature on fertility outcome in HCT survivors and the associated risk factors.


Hematopoietic cell transplantation, Prepubertal, Spontaneous pregnancy

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