Study of liver function tests in hypertensive disorders of pregnancy
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20180920Keywords:
LFTs, Hypertensive disorders, Pre eclampsia, PregnancyAbstract
Background: Hypertensive disorders of pregnancy with spectrum complications is one among leading causes of feto-maternal morbidity and mortality especially when its associated with HELLP syndrome.
Methods: The present prospective study was conducted over a period of three years in the department of obstetrics and gynecology at Chalmeda Anandarao Institute of Medical Sciences, Karimnagar, Telangana from January 2008 to January 2009. This is a prospective study on 50 pregnant women with 28-40 weeks of gestation with diastolic BP ≥110 mm Hg recorded 6 hours apart.
Results: This is a prospective study on 50 pregnant women with 28-40 weeks of gestation with diastolic BP≥110 mm Hg recorded 6 hours apart. Severe pre eclampsia was seen in younger age group ˂25 years. In patients with raised LFTs unbooked cases were more (64%) showing complications are more in unbooked cases. Renal complications are seen in 16% of the total cases and in 28% of the cases with raised LFTs. In overall study group number of primi gravid were 50% and multi were 27%. Incidence of severe pre eclampsia was 78% in overall cases. In patients with raised LFTs the incidence was 30 (88%).
Conclusions: Detection of increased LFTs in cases of severe pre-eclampsia is a risk category, associated with increased rate of feto-maternal complications, compared to severe pre-eclampsia with normal LFTs. Such cases need special attention with early detection and referral to higher centre with better facilities of NICU set up to reduce the complications and mortality.
Metrics
References
Aamoudse JG, Hollthoff. A syndrome of liver damage and intra vascular coagulation in the trimester of normotensive pregnancy. A clinical histopathological study. Br J Obstet Gynecol. 1986;93:45-55.
Adlercreutz H, Tenhunen R. Some Spaects of interaction between natural and synthetic female sex hormones and the liver. Am J Med. 1970;49:620.
Aias F, Mancilla-Jimmenez R. hepatic fibrinogen deposits in pre-eclampsia. N Engl J Med. 1976;295:578.
Antia FP, Bharadwaj TP, Watsa MC, Master J. Liver in normal pregnancy, preeclampsia and eclampsia. Lancet. 1958 Oct 11;272(7050):776-8.
MacGillivray I. Hydramnios and preeclampsia Lancet. 1959:52-3.
Dutta DC. Text book of obstetrics; 4th ed. Elsevier India;2013.
Arias F, Mancilla-Jimenez R. Hepatic fibrinogen deposits in pre-eclampsia. N Engl J Med. 1976;295:578.
Audibert F, Friedman SA, Frangieh AY, Sibai BM. Clinical utility of strict diagnosis criteria for the HELLP (hemolysis, elevated liver enzyme and low platelets) syndrome. Am J Obstet Gynecol. 1996;175:460-4.
Beller FK, Dame WR, Ebert C. pregnancy inducd hypertension complication by thrombocytopenia. Renal biopsies and outcome. Aust NZ J Obstet Gynecol. 1985;25:83.
Borglin NE, Serum transaminase activity in uncomplicated and complicated pregnancy and in new born. J clin endocrine metab, 1958; 18:872-7.
Broughton Pipkin F. Risk factors for pre eclampsia. N Engl J Med. 2001;344:925.
Carter I. Liver function in normal pregnancy. Aust NZ J Obstet Gynecol. 1990;30:296-302.
Calbereath DF. Clinical chemistry a fundamental text book. W.B. Saunders;1992:227-32.
Goodlin RC, Cotton DB, Haesslein HC. Severe oedema proteinuria-Hypertension gestosis. Am J Obstet Gynecol. 1978;132:595.