Published: 2018-10-25

Preterm premature rupture of membranes: maternal and perinatal outcome

Shweta Avinash Khade, Amarjeet Kaur Bava


Background: This is an observational analytical study carried out in department of obstetrics and Gynecology, in a tertiary care center to determine the factors influencing fetal and maternal outcome, prognosis and complications in preterm premature rupture of membrane cases.

Methods: The present study is a prospective observational study of perinatal and maternal outcome in 100 cases of preterm premature rupture of membranes in between 2837 weeks gestation with singleton pregnancy, from 1st March 2013 to 28th February 2014. Patients with medical complications like anemia, preexisting hypertension, diabetes, vascular or renal disease, multiple gestations, uterine or fetal anomalies etc. are excluded from the study. Detailed history, physical examinations were carried out and appropriate management instituted as per individual patients need.

Results: In this study maternal morbidity was 16%. Perinatal morbidity was 33% and most common causes were hyperbilirubinemia (23%), RDS (21%).  Perinatal mortality was seen in 15% and mainly due to RDS (53%). Twenty-five (25%) neonates were delivered by cesarean. The main indications for cesarean being malpresentation (36%) followed by fetal distress (24%).

Conclusions: PPROM is one of the important causes of preterm birth that can result in high perinatal morbidity and mortality along with maternal morbidity. Looking after a premature infant puts immense burden on the family, economy and health care resources of the country. An understanding of gestational age dependent neonatal morbidity and mortality is important in determining the potential benefits of conservative management of preterm PROM at any gestation.


Mortality, Perinatal morbidity, Prom

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Caughey AB, Robinson JN, Norwitz ER. Contemporary Diagnosis and Management of Preterm Premature Rupture of Membranes. Rev. Obstet Gynecol. 2008;1(1):11-22.

Fernando Arias; Premature rupture of the membrane, “Practical guide to high risk pregnancy and delivery”.3rd Ed; Elsevier, New Delhi, 2008; 220-237.

Pandey S, Dave A, Bandi S. Maternal and fetal outcome in cases of preterm premature rupture of membranes. J Obstet Gynaecol India. 2000;50:63.

Noor S, Fawwad A, Shahzad H, Sultana R, Bashir R. Foetomaternal outcome in patients with or without premature rupture of membranes. J Ayub Medical College Abbottabad. 2010;22(1):164-7.

Okeke TC, Enwereji JO, Okoro OS, Adiri CO, Ezugwu EC, Agu PU, et al. The incidence and management outcome of preterm premature rupture of membranes in a tertiary hospital in Nigeria. Am J Clinic Med Res. 2014;(2)1:14-17.

Triniti A, Suthatvorawut S, Pratak O. Epidemiologic study of cervical swab culture in preterm premature rupture of membrane (PPROM) at Ramathibodi Hospital. Thai J Obstet Gynaecol. 2008;16(3):173-8.

Kadikar GK, Gandhi MR, Damani SK. A Study of Feto-Maternal Outcome in Cases of Premature Rupture of Membrane. IJSR. 2014;3(3):299-301

Carroll SG, Philpott-H J, Nicolaides KH. Amniotic fluid gram stain and leukocyte count in the prediction of intrauterine infection in preterm prelabour amniorrhexis. Fetal Diag Therapy. 1996;11(1):1-5.

Kamala Jayaram, Scaila Sudha, A study of premature rupture of membranes Management and outcome. J Obstet Gynaecol India. 2001;51(2):58-60.

ACOG Committee on Practice Bulletins –Obstetrics, authors. Clinical Management guidelines for Obstetrician-Gynecologists. (ACOG Practice Bulletin No 80: premature rupture of membranes). Obstet Gynecol. 2007;109(4):1007-19.

Tavassoli F, Ghasemi M, Mohamadzade A, Sharifian J. Survey of pregnancy outcome in preterm premature rupture of membrane in AFI <5 and >5. Oman Med J. 2010; 25(2):118-23.

Anjana D, Reddi R. Premature rupture of membrane: A clinical study. J Obst Gynecol India 1996;46:63-76.

Kumaran A, Penna LK. prelabor ROM. Management of labor, Orient Longman. 2005:306-18.

Russell KP, Anderson GV. The aggressive management of ruptured membranes. Am J Obstet Gynecol. 1962;83(7):930-7.