Assessment of pregnancy outcome with low molecular weight heparin therapy: a retrospective, single centre observational study


  • Ankita Singh Department of Obstetrics and Gynecology, Sri Aurobindo Medical College and PG Institute, Indore, India
  • Madhuri Alwani Department of Obstetrics and Gynecology, Sri Aurobindo Medical College and PG Institute, Indore, India
  • Nutan Yadav Department of Obstetrics and Gynecology, Sri Aurobindo Medical College and PG Institute, Indore, India
  • Priyam Padia Department of Obstetrics and Gynecology, Sri Aurobindo Medical College and PG Institute, Indore, India



Low molecular weight heparin therapy, Pregnancy, Thromboembolism


Background: The objective of this study was to determine the outcomes of Low Molecular Weight Heparin Therapy (LMWH) given for various indications during pregnancy.

Methods: In this context, a detailed retrospective analysis of all the patients who received LMWH for various indications over a period of two years from October 2015 to November 2017 at a single center, Sri Aurobindo Medical College and PG institute in Indore was performed.

Results: Total 100 patients were studied, included over the period of 2 years for various indications for which Enoxaparin (1 mg/kg body weight OD/BD subcutaneously) was used. The indications were valvular heart disease with valve replacement and atrial fibrillation (54.0%), chronic deep vein thrombosis (DVT) (13.0%), thrombophilias (9.0%), recurrent pregnancy loses (21.0%) and prophylaxis for deep vein thrombosis (3.0%) in overall patients. Abortion was seen in 8.0 % patients; fetal growth restriction in 13% patients; and oligohydramnios, preeclampsia, gestational hypertension, placenta previa, abruptio placentae, postpartum hemorrhage patients and Stillbirth occurred in 4.0 % patients. No thromboembolic event was noted in any of the patients. None of the patients had any documented thrombocytopenia or clinical fracture.

Conclusions: Low Molecular Weight Heparin Therapy (LMWH) used amongst pregnant women with various indications for anticoagulation therapy was associated with successful pregnancy outcome in the vast majority of cases. Further multicenter prospective studies and international registries of pregnant women on LMWH are necessary to broaden our knowledge in optimizing the care of women who require anticoagulation during pregnancy.


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Original Research Articles