Prevalence of congenital anomalies in a tertiary care centre in North Kerala, India
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20180411Keywords:
Congenital anomaly, Pattern of prevalence, Risk factorsAbstract
Background: Congenital anomalies have emerged as an important cause for neonatal morbidity and mortality. The prevalence as well as pattern of anomaly varies from place to place. Literature search reveals that India has the highest number of children with birth defects.
Methods: This is a cohort study conducted in the Department of Obstetrics and Gynecology during the period 2009-2015. All mothers admitted with congenital structural defects to the fetus diagnosed by imaging and those who delivered anomalous babies were included in this study. The anomalies were classified based on ICD-10 system.
Results: There were a total of 911 anomalous babies born during the study period of which 554 were males and 338 were females.19 babies had ambiguous genitalia. Anomalies were more common in multigravidae and in mothers of age group 20-29 years. Maximum number of babies were born between 37-40weeks. Maternal diabetes was associated with increased incidence of anomalies. Most common system involved was urinary system followed by musculoskeletal system.
Conclusions: The prevalence of structural anomalies in the present study is 0.84%. Patients with risk factors for anomalies should undergo pre-pregnancy counselling. Routine antenatal anomaly screening with ultrasound before viability should be done for all patients so that early termination of lethal anomalies can be done.
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References
Dastgiri S, Sheikhzadeh Y, Dastgiri A. Monitoring of congenital anomalies in developing countries: a pilot model in Iran. InITCH. 2011;164:157-61.
Global Burden of Disease Pediatrics Collaboration, Kyu HH, Pinho C, Wagner JA, Brown JC, Bertozzi-Villa A et al. Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013: Findings From the Global Burden of Disease 2013 Study. JAMA Pediatr. 2016;170(3):267-87.
Patel ZM, Adhia RA. Birth defects surveillance study. Indian J Pediatr. 2005;72:489-91.
World Health Organization. Section on congenital anomalies. [Cited on 2016 September]. Available at http://www.who.int/mediacentre/factsheets/fs370/en/
Park K. Congenital malformations. In K Park’s Text book of Preventive and Social Medicine, 15th ed. 2005:379-80.
Carmona RH. The global challenges of birth defects and disabilities. Lancet. 2005 Oct;366(9492):1142-4.
Christianson AL, Howson CP, Modell B. March of Dimes: global report on birth defects, the hidden toll of dying and disabled children. March of Dimes: global report on birth defects, the hidden toll of dying and disabled children. 2005. Available at http://www.marchofdimes.com/downloads/Birth_Defects_Report-PF.pdf. Accessed on 20 April 2016.
Prajapati VJ, Kacha AR, Kakkad KM, Damor PB, Nandaniya AM. Study of Congenital Malformation in Neonates Born at Tertiary Care Hospital. Natl J Community Med. 2015;6(1):30-4.
Penchaszadeh VB. Preventing congenital anomalies in developing countries. Community Genet. 2002;5:61-9.
Kar A, Preventing Birth Defects in India. Econo Politic Week. 2011;46(48).
Bhat BV, Ravikumara M. Perinatal mortality in India-Need for introspection. Indian J Matern Child Health. 1996;7:31-3.
Agarwal SS, Singh U, Singh PS, Singh SS, Das V, Sharma A, et al. Prevalence and spectrum of congenital malformations in a prospective study at a teaching hospital. Indian J Med Res. 1991;94:413-9.
Taksande A, Vilhekar K, Chaturvedi P, Jain M. Congenital malformations at birth in Central India: A rural medical college hospital based data. Indian J Hum Genet. 2010;16:159-63.
Chaturvedi P, Banerjee KS. Spectrum of congenital malformations in the newborns from rural Maharashtra. Indian J Pediatr. 1989;56:501-7.
Khatemi F, Mamoori GA. Survey of congenital major malformations in 10/000 newborns. Iran J Pediatr. 2005;15:315-20.
Tomatir AG, Demirhan H, Sorkun HC, Köksal A, Ozerdem F, Cilengir N. Major congenital anomalies: A five-year retrospective regional study in Turkey. Genet Mol Res. 2009; 8:19-27.
Dutta V, Chaturvedi P. Congenital malformations in [7] rural Maharashtra. Indian Pediatr. 2000;37:998-1001.
Mohanty C, Mishra OP, Das BK, Bhatia BD, Singh G. Congenital malformation in newborn: A study of 10,874 consecutive births. J Anat Soc India. 1989;38:101-11.
Biri A, Onan A, Korucuoglu Ü, Tiras B. Birth prevalence and distribution of congenital anomalies in a university hospital. Perinatol Dergisi. 2005;13:86-90
Prajapati VJ, Kacha AR, Kakkad KM, Damor PB, Nandaniya AM. Study of congential malformations in neonates born at tertiary care hospital. Natl J Community Med. 2015;6(1):30-4.
Swain S, Agarwal A, Bhatia BD. Congenital malformation at birth, Indian Pediatr. 1994;31:1187-91.
Savaskar SV, Mundada SK, Pathan AS, Gajbhiye SF. Study of various antenatal factors associated with congenital anomalies born at tertiary health centre. Int J Recent Trends Sci Technol. 2014;12(1):82-5.
Parmar A, Rathod SP, Patel SV, Patel SM. Study of congenital anomalies in newborn. NJIRM. 2010;1(1):13-7.
Padma S, Ramakrishna D, Jijiya P, Ramana PV. Pattern of distribution of congenital anomalies in still born: a hospital based prospective study. Int J Pharma Bio Sci. 2011;2:604-10.
Kulshreshtha R, Nath LM, Upadhyaya P. Congenital Malformation in live born infants in a rural community. Indian Pediatr. 1982;19:1003-9.
Verma M, Chhatwal J, Singh D. Congenital malformations – a retrospective study of 10,000 cases. Indian J Pediatr. 1991;58:245-52.
Gupta S, Gupta P, Soni JS. A study on incidence of various systemic congenital malformations and their associations with maternal factors. Nat J Med Res. 2012;2(1):19-21.
Sharpe PB, Chan A, Haan EA, Hiller JE. Maternal diabetes and congenital anomalies in South Australia 1986–2000: a population-based cohort study. Birth Defects Res. 2005;73:605-11.
Mazor M, Hagay ZJ, Leiberman JR, Baile Y, Insler V. Fetal malformations associated with breech delivery. Implications for obstetric management. J Reprod Med. 1985 Nov;30:884-6.
Hsieh YY, Tsai FJ, Lin CC, Chang FC, Tsai CH. Breech deformation complex in neonates. J Reprod Med. 2000 Nov;45:933-5.
Late Intrauterine Fetal Death and Stillbirth (Green-top Guideline No. 55);2010. Available at https://www.rcog.org.uk/en/guidelines-research-services/guidelines/gtg55/
Wills V, Abraham J, Sreedevi NS. Congenital anomalies: the spectrum of distribution and associated maternal risk factors in a tertiary teaching hospital. Int J Reprod Contracept Obstet Gynecol. 2017 Mar 30;6(4):1555-60.
Mashuda F, Zuechner A, Chalya PL, Kidenya BR, Manyama M. Pattern and factors associated with congenital anomalies among young infants admitted at the Bugando Medical Centre, Mwanza, Tanzania. BMC Res Notes. 2014;7:195.
Bhide P, Gund P, Kar A. Prevalence of congenital anomalies in an Indian maternal cohort: healthcare, prevention, and surveillance implications. PloS one. 2016 Nov;11(11):e0166408.