Published: 2018-07-26

Three consecutive pregnancies having arthrogryposis multiplex congenita

Sunil K. Juneja, Pooja Tandon, Shirin Garg


Arthrogryposis Multiplex Congenita is a syndrome or disorder that presents with multiple congenital joint contractures at birth. It is X-linked recessive disorder, non-progressive and is of variable severity. Here is a case report with three consecutive pregnancies having fetus affected with Arthrogryposis Multiplex Congenita (AMC) diagnosed antenatally. Arthrogryposis Multiplex Congenita affects 1 in 3000 live births. During embryogenesis, joint development is normal. Motion is essential for the normal development of joints and surrounding structures. Fetal akinesia causes extra connective tissue to develop around the joint. This results in fixation of the joint and a further increase in the contracture. Earlier in pregnancy the contractures form, worse is the prognosis.


Arthrogryposis multiplex congenita, Contractures, Fetal akinesia

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Hall JG. Arthrogryposis multiplex congenita: etiology, genetics, classification, diagnostic approach, and general aspects. J Pediatr Orthoped. Part B. 1997;6(3):159-66.

Bamshad M, Van Heest AE, Pleasure D. Arthrogryposis: a review and update. J Bone Joint Surg Am Vol. 2009 ;91(Suppl 4):40.

Bevan WP, Hall JG, Bamshad M, Staheli LT, Jaffe KM, Song K. Arthrogryposis multiplex congenita (amyoplasia): an orthopaedic perspective. J Pediatr Orthopaed. 2007;27(5):594-600.

Mallia Milanes G, Napolilano R, Quagliaf et al. Prenatal diagnosis of Arthrogryposis. Minerva Ginecol. 2007;59(2):203-4

Kalampokas E, Kalampokas T, Sofoudis C, Deligeoroglou E, Botsis D. Diagnosing arthrogryposis multiplex congenita: a review. ISRN Obstetr Gynecol. 2012;2012.

Thompson GH, Bilenker RM. Comprehensive management of arthrogryposis multiplex congenita. Clin Orthopaed Related Res. 1985;(194):6-14.

Fassier A, Wicart P, Dubousset J, Seringe R. Arthrogryposis multiplex congenita. Long-term follow-up from birth until skeletal maturity. J Children's Orthopaed. 2009;3(5):383-90.

Rahman T, Sample W, Jayakumar S, King MM. Passive exoskeletons for assisting limb movement. J Rehabilitat Res Dev. 2006;43(5):583.

Jean-Francois, Edvige. Robot exoskeleton lets girl lift her arms, reach for the stars". CNN. 2014. Retrieved 10 May 2017.

Chen Eli. Building functional, fashionable exoskeletons for babies". News Works. The Pulse. 2016. Retrieved 10 May 2017.

Parsch K, Piretrzak S. Congenital Multipex Arthrogryposis. Orthopede. 2007;36(3): 281-90.