Evaluation of serum lipids in preeclampsia: a comparative study
Keywords:Lipid profile, Preeclampsia, Triglycerides, Total Cholesterol
Background: Preeclampsia occurs in 7 to 10% of pregnancies worldwide. At present most, popular theory is an oxidative stress. Abnormal lipid profiles and species may have a role in promotion of oxidative stress and vascular dysfunction seen in pre-eclampsia. Objectives of this study was carried out to evaluate lipid profile in subjects with preeclampsia and to compare lipid profile in subjects of preeclampsia as compared to normal pregnant women.
Methods: A comparative longitudinal study was conducted under the tertiary care hospital setting over a period of one year where 440 study subjects were enrolled out of which 220 subjects were pre-eclamptic and 220 subjects were normotensive with gestation of 28 weeks to till term. Lipid profiling was done in all the subjects.
Results: The mean serum levels of total cholesterol (198.5±18.91), HDL (50.63±9.35), LDL (84.5±16.16), VLDL (42.75±4.72) and TGA (74.92±11.95) were higher in pre-eclampsia group compared to normotensive group and this difference in the levels of lipid parameters was found to be statistically significant.
Conclusions: Dyslipidemia is significantly evident in preeclampsia and plays an important role in its pathogenesis.
Vanderjagt DJ. HDL and homocysteine levels correlate inversely in preeclamptics women in North Nigeria. Acta Obstet Gynecol Scand. 2004;83:536-42.
Mutlu-Turkoglu U, Ademoglu E. Imbalance between lipid peroxidation, antioxidant status in preeclampsia. Gynecol Obstet Invest. 1998;46:37-40.
Ghosh MK. Maternal mortality: a global perspective. J Reprod Med. 2001;46(5):427-33.
Zhang J. Partner change, birth interval and risk of pre-eclampsia: a paradoxical triangle. Paediatr Perinat Epidemiol. 2007;21:31-5.
Belo L, Caslake M, Gaffney D, Santos-Silva A, Pereira-Leite L, Quintanilha A, et al. Changes in LDL size and HDL concentration in normal and preeclamptic pregnancies. Atherosclerosis. 2002;162(2):425-32.
Seely EW, Solomon CG. Insulin resistance and its potential role in pregnancy-induced hypertension. J Clin Endocrinol Metab. 2003;88(6):2393-8.
Kshinakunti SV, Sunitha H, Gurupaddappa K, Manjula R. Lipid Profile In Preeclampsia-Case Control Study. Journal of Clinical and Diagnostic Research. 2010;4:2748-51.
Qiu C, Phung TT, Vadachkoria T. Oxidised low densitylipoprotein and the risk of Preeclampsia. Physiol Res. 2005.
Isomaa B, Almgren P, Tuomi T, Forsen B, Lahti K, Nissen M, et al. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care. 2001;24(4):683-9.
Girman CJ, Rhodes T, Mercuri M, Pyorala K, Kjekshus J, Pedersen TR, et al. The metabolic syndrome and risk of major coronary events in the scandinavian simvastatin survival study (4S) and the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS). Am J Cardiol. 2004;93(2):136-41.
Anjum R, Zahra N, Rehman K, Alam R, Parveen A, et al. Comparative analysis of serum lipid profile between normotensive and hypertensive Pakistani pregnant women. J Mol Genet Med. 2013;7:64.
Mikhail MS, Basu J, Palan PR, Furgiuele J, Romney SL, Anyaegbunam A. Lipid profile in women with preeclampsia: relationship between plasma triglyceride levels and severity of preeclampsia. Journal of the Association for Academic Minority Physicians: the official publication of the Association for Academic Minority Physicians. 1995;6(1):43-5.
Gohil JT, Patel PK, Priyanka G. Lipid profile in patients of preeclampsia. Journal of Obstetrics and Gynecology of India. 2011;61(4):399-403.
Enquobahrie DA, Williams MA, Butler CL, Frederick IO, Miller RS, et al. Maternal plasma lipid concentrations in early pregnancy and risk of preeclampsia. Am J Hypertens. 2004;17:574-81.
De J, Mukhopadhyay A, Saha PK. Study of serum lipid profile in pregnancy induced hypertension. Indian J Clin Biochem. 2006 Sep 1;21(2):165.