A comparative study of oral iron and intravenous iron in iron deficient antenatal mothers


  • Suganya G. Department of Obstetrics and Gynecology, Vinayaka Mission Kirupanandha Variyar Medical College and Hospital, Salem, Tamil Nadu, India
  • D. Vimala Department of Obstetrics and Gynecology, Vinayaka Mission Kirupanandha Variyar Medical College and Hospital, Salem, Tamil Nadu, India




Antenatal mothers, Intravenous iron, Oral iron


Background: The aim of the study is to compare the efficacy, tolerance and compliance between oral iron and intravenous infusion of iron in iron deficient antenatal mother.

Methods: This is a prospective randomised clinical and interventional study in the department of Obstetrics and Gynaecology in Vinayaka Mission Kirupananda Variyar Medical College and Hospital. The antenatal women attending the antenatal op were screened for Hb status. Those antenatal women of gestational age 16-34 weeks with Hb level between 7-10g% and diagnosed to have iron deficiency anemia by peripheral smear and serum ferritin were included in this study after getting informed consent. The total numbers of 100 mothers were allotted into two major groups, group A and group B of 50 subjects each. Group A: 50 pregnant women given oral iron supplementation (carbonyl iron 100 mg twice a day). Group B: 50 pregnant women given intravenous iron sucrose therapy after calculating the total iron requirement. The rise in hemoglobin in both the groups were compared

Results: In this study the mean rise of hemoglobin in carbonyl iron was 0.914±0.20 gm% whereas in iron sucrose group was 2.43±0.20gm%. This showed that iron sucrose (i.v) had better rise in Hb than carbonyl iron (oral).

Conclusions: The present study revealed that intravenous iron sucrose therapy was better

tolerated with higher increase in mean haemoglobin compared to oral iron therapy. There were no serious side effects with intravenous iron sucrose therapy. Intravenous iron sucrose is a good substitute to oral iron therapy in moderate anaemia.


Malviya MK, Bhardwaj VK, Chansoria M, Khare S. Anthropometric profile and perinatal outcome of babies born to young women (< 18 years). Indian Paediatr. 2003;40(10):971-6

Singh K, Fong YF, Arulkumaran S. Anaemia in pregnancy - a cross-sectional study in Singapore. Eur J Clin Nutr. 1998;52(1):65-70.

Wali A, Mustaq A, Nilofer (Aga Khan hospital for Women and Children,Kharadar, Karachi: A unit of Agha Khan Health Service, Pakistan).Comparative study - Efficacy,Safety and Compliance of Intravenous Iron Sucrose and Intramuscular Iron Sorbitol in Iron Deficiency Anaemia of Pregnancy. J Pak Med Assoc. 2002 Sep;52(9):392-5

Al-Momen AK, Huraib SO, Mitwalli AH, Al-Wakeel J, A1-Yamani M, Abu-Aisha H, Said R. Intravenous iron saccharate in hemodialysis patients receiving r-HuEPO. Saudi J Kidney Transplant 1994;5:168-72.

Danielson B. Intravenous iron therapy-efficacy and safety of iron sucrose. In Prevention and Management of Anaemia in Pregnancy and Postpartum Haemorrhage. 1998:93-106.

Hoigne R, Breymann C, Künzi UP, Brunner F. Parenteral iron therapy: problems and possible solutions. Schweizerische Medizinische Wochenschrift. 1998 Apr;128(14):528-35.

Bayoumeu F, Subiran-Buisset C, Baka NE, Legagneur H, Monnier-Barbarino P, Laxenaire MC. Iron therapy in iron deficiency anaemia in pregnancy: intravenous route versus oral route. Am J Obstet Gynecol. 2002;88:3-10

Gordeuk VR, Brittenham GM, Hughes MA, Keating LJ. Carbonyl iron for short term supplementation in female blood donors. Transfusion. 1987;27:80-5.

Kochhar PK, Kaundal A, Ghosh P. Intravenous iron sucrose versus oral iron in treatment of iron deficiency anemia in pregnancy: a randomized clinical trial. J Obstet Gynaecol Res. 2013 Feb 1;39(2):504-10.

Perewusnyk G, Huch R, Huch A, Breymann C. Parenteral iron therapy in obstetrics: 8 years experience with iron–sucrose complex. Br J Nutr. 2002 Jul;88(1):3-10.






Original Research Articles