Serum beta hCG in early second trimester as a predictor of gestational hypertension
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20182349Keywords:
Gestational hypertension (GH), hCGAbstract
Background: Hypertensive disorders of pregnancy complicate upto 10% of pregnancies worldwide, and constitute one of the greatest causes of maternal and perinatal morbidity and mortality. The goal of this study is to evaluate the serum beta hCG levels in pregnant women as a predictor of gestational hypertension.
Methods: This is a prospective study done at K. S. Hegde Medical Academy during the month of November 2015 to January 2017. Serum beta hCG was estimated between 14-20 weeks of gestation in 90 women with singleton pregnancy irrespective of parity. Regular follow up of the cases were done till delivery. Results were analysed statistically.
Results: Out of 90 women, 81 women were followed till term and 12 (14.8%) cases developed gestational hypertension. β HCG levels (Mean±SD) were higher (69808.66±54764.7 vs. 38126.49±97419.2; p<0.28) in subjects who developed gestational hypertension. Serum beta hCG (median >32726 mIU/ml) has a sensitivity of 75%, specificity of 72.5% and accuracy of 72.8%.
Conclusions: Our study indicate an increased risk of gestational hypertension in women with elevated levels of serum beta hCG. As yet there are no practically acceptable and reliable screening tests for gestational hypertension, serum beta hCG seems to be good noninvasive early predictor for the development of gestational hypertension.
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References
Leela KP, Devi GR, Neeraja M. Study of serum lipid profile in early second trimester as predictor of hypertensive disorders complicating pregnancy. Int J Preclin Pharmaceutical Res. 2012;3(2):114-7.
Choudhury KM, Das M, Ghosh S, Bhattacharya D, Ghosh T K. Value of Serum β-hCG in Pathogenesis of Pre-Eclampsia. J Clin Gynecol Obstetrics. 2012;1:71-5.
Cunningham FG, Leveno KJ, Bloom SL, Hauth JC. Hypertensive disorders of pregnancy. In: Cunningham F, Williams G III, J eds. Williams Obstetrics. 23rd ed; 2009:706-709
Dekker GA, Sibai BM. Early detection of preeclampsia. AJOG. 1991;165:160-72.
Braunstein GD, Rasor J. Serum human chorionic gonadotropin levels throughout normal pregnancy. AJOG. 1976;126:678-81.
Swets J. Measuring default accurately. Risk; 2001: 31-33.
Vidyabati RK, Davina H, Singh NK, Gynaehswar SW. Serum β hCG and lipid profile in second trimester as predictors of pregnancyinduced hypertension. J Obstet Gynecol India. 2010;60:44-50.
Satyanarayan K, Sawhney H, Vasishta K. Association between second trimester maternal serum hCG levels and PIH. J Obst Gyn India. 2001;51:85-8.
Gurmandeep K, Vimla J, Seema M. Prediction of PIH by maternal serum βhCG levels in the second trimester of pregnancy. JOGI. 2012;62:52-4.
Desai P, Rao S. Predictive value of raised midtrimester β hCG in PIH. JOGI. 2002;52:68-72.
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