Primary tubal choriocarcinoma
Keywords:Choriocarcinoma, Ectopic pregnancy, Fallopian tube, Gestational trophoblastic disease
Choriocarcinoma is extremely aggressive form of gestational trophoblastic disease. It occurs due to neoplastic changes in the chorionic villi. The most common site of origin is uterus but rarely can occur in tube, cervix or ovary. Tubal choriocarcinoma may develop either by malignant transformation of a tubal pregnancy or can arise denovo without an ectopic pregnancy. The reported incidence of tubal choriocarcinoma is approximately 1.5/1,000,000 births. Here, we report a case in which salphingectomy was done thinking it was an acute ectopic pregnancy, but histopathological examination showed tubal choriocarcinoma. This tubal choriocarcinoma occurred denovo and was not secondary to an ectopic pregnancy. Patient did not need adjuvant chemotherapy as it was detected early and is being followed up by β-hcg monitoring.
Mehrotra S, Singh U, Goel M, Chauhan S. Ectopic tubal choriocarcinoma: a rarity. BMJ case reports. 2012;bcr-2012-006318.
Nayama M, Lucot JP, Boukerrou M, Collinet P, Cosson M, Vinatier D. Tubal choriocarcinoma: a case reporteview of the literature. J Gynecol Obstet Biol Reprod. 2007;36(1):83-6.
Chen MJ, Yang JH, Lin MC, Ho HN, Yang YS. An unusual gestational choriocarcinoma occurring primarily on the surface of a subserous leiomyoma. BJOG: Int J Obst Gynaecol. 2004;111(2):188-90.
Karaman E, Çetin O, Kolusari A, Bayram I. Primary tubal choriocarcinoma presented as ruptured ectopic pregnancy. J Clin Diag Res. 2015;(9):QD17.
Meddeb S, Rhim MS, Zarrouk W, Bibi M, Yacoubi MT, Khairi H. Unusual gestational choriocarcinoma arising in an interstitial pregnancy. Int J Surgery case Reports. 2014;5(11):787-8.
Tasha I, Kroi E, Karameta A, Shahinaj R, Manoku N. Prevalence of gestational trophoblastic disease in ectopic pregnancy. J Prenat Med. 2010;4(2):26.
Beena D, Teerthanath S, Jose V, Shetty J. Molar pregnancy presents as tubal ectopic pregnancy: a rare case report. J Clin Diag Res. 2016;10(1):ED10.
Galvez CR, Fernandez VC, De Los Reyes JM, Jaén MM, Teruel RG. Primary tubal choriocarcinoma. International J Gynecol Can. 2004;14(5):1040-4.
Hook J, Seckl M. Management of trophoblastic disease. IN: Dunlop W, Ledger EL. eds. Recent advances of obstetrics and gynecology. London: The royal society of medicine press Ltd. 2008;24:147-148.
Nakayama M, Namba A, Yasuda M, Hara M, Ishihara O, Itakura A. Gestational choriocarcinoma of Fallopian tube diagnosed with a combination of p57KIP2 immunostaining and short tandem repeat analysis: case report. 2011;37(10):1493-6.