DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20182916

A rare case of urothelial carcinoma arising in mature cystic teratoma

Nitesh R. Maurya, Urvi C. Bhavsar

Abstract


Mature cystic teratoma is a common benign adnexal tumour in females. It is composed of all the three germ layers (mesoderm, endoderm and ectoderm). Malignant transformation in a mature cystic teratoma of the ovary is rare, occurring in only 1-2% of cases. The most common malignancy is squamous cell carcinoma, which consists of about 80% of malignant transformations. Here we report malignant transformation of MCT in a 74year old post-menopausal female. Grossly the ovary was large cystic occupying the entire abdomen. Trial dissection was done and only 50% of the mass could be dissected due to gross adhesions. HPE reported as urothelial carcinoma in mature cystic teratoma. MCT is easily diagnosed via sonography, but malignant transformation is difficult to identify before surgery. For patients with malignant transformation, squamous cell carcinoma is the most common malignancy arising from MCT, and accounts for 80% of all cases. Other malignancies, such as adenocarcinomas, sarcomas or malignant melanomas have been reported; however, urothelial carcinoma arising from MCT is rare.


Keywords


Germ cell tumors, Mature cystic teratoma, Urothelial carcinoma

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References


Chuang HY, Chen YT, Mac TL, Chen YC, Chen HS, Wang WS et al. Urothelial carcinoma arising from an ovarian mature cystic teratoma. Taiwanese J Obstet Gynecol. 2015;54:442-4.

Lee OJ, Lee HC. Urothelial (transitional cell) carcinoma arising in mature cystic teratoma: A case report. Korean J Pathol. 2010;44:666-9.

Park SB, Kim JK, Kim KR Cho KS. Preoperative diagnosis of mature cystic teratoma with malignant transformation: analysis of imaging findings and clinical laboratory data. Arch Gynecol Obstet. 2007;275:25-31.

Al-Rayyan ES, Duqoum WJ, Sawalha MS, Nascimento MC, Pather S, Dalrymple CJ, et al. Secondary malignancies in ovarian dermoid cyst. Saudi Med J. 2009;30:524-8.

Hackethal A, Brueggmann D, Bohlmann MK, Franke FE, Tinneberg HR, M├╝nstedt K, et al. Squamous cell carcinoma in mature cystic teratoma of ovary: systematic review and analysis of published data. Lncet Oncol. 2008;9:1173-80.

Eichhorn JH, Young RH. Transitional cell carcinoma of ovary and a morphologic study of 100 cases with emphasis on differential. Am j Surg Pathol. 2004;28:453-63.

Kido A, Togashi K, Konishi I, Kataoka ML, Koyama T, Ueda H, et al. Dermoid cyst of the ovary with malignant transformation: MR appearance. AJR Am J Roentgenol. 1999;172:445-9.