A case control study to evaluate correlation of anemia with severe preeclampsia

Garima Gupta

doi:10.18203/2320-1770.ijrcog20182879

Authors

Garima Gupta Department of Obstetrics and Gynecology, Gandhi Medical College, Bhopal, Madhya Pradesh, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20182879

Keywords:

Acute renal failure, Anemia, Preeclampsia, Small for date

Abstract

Background: Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality worldwide. This study aims to evaluate correlation of anemia with severe preeclampsia.

Methods: It is a prospective case control study conducted in Sultania Zanana Hospital, Bhopal over one year period. Patients were grouped as cases (severe preeclampsia with severe anemia, n=180) and controls (severe preeclampsia with no/mild/moderate anemia, n=180). Collecting data were compared using the Pearson chi square, fisher’s exact test and the independent t-test as appropriate. Logistic regression analysis was performed. Odds ratio (OR) and their corresponding 95% confidence intervals were calculated.

Results: Higher incidence of maternal complications abruption (8.88% v/s 0.5%), ARF (2.2% v/s 0.5%), PPH (2.8%), pulmonary edema (5%), CCF (3.3%), HELLP (1.6%), CVA (1.1%), pulmonary embolism and DIC in 0.5% and maternal mortality seen in cases. Perinatal complications like pregnancy wastage (22.8% v/s 7.8%), IUGR (55.8% v/s 32%), early neonatal death (7.5% v/s 2.4%), NICU admission (31.3% v/s 20.7%) were more in cases.

Conclusions: Perinatal and maternal complications are significantly associated with severity of anemia in preeclampsia women. Anemia being a easily detectable and modifiable risk factor, detection of anemia in early gestation can be a key to prevent or decrease the severity of preeclampsia.

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References

Prakash J, Vohra R, Pandey LK, Niwas SS, Behura SK, Singh U. Spectrum of kidney diseases in patients with preeclampsia-eclampsia. J Assoc Physicians India. 2010;58:543-6.

Mudaliar and Menon. The evaluation of treatment of eclampsia. Brit J Obstet Gynaecol. 1961;68:417.

World Health Organization (WHO). World health report 2005: make every mother and child count. Geneva: WHO; 2005: 63

Enaruna NO, Sodje JD. Early-Onset Severe Preeclampsia in Nigerian Women: Determining a Balance between Maternal Wellbeing and Fetal Survival in a Resource-Limited Setting. British J Med Med Res. 2015;10(3):1-9.

Assis TR, Viana FP, Rassi S. Study on the major maternal risk factors in hypertensive syndromes. Arq Bras Cardiol. 2008;91(1):11-7.

Tebeu PM, Foumane P, Mbu R, Fosso G, Biyaga PT, Fomulu JN. Risk factors for hypertensive disorders in pregnancy: a report from the Maroua Regional Hospital, Cameroon. J Reprod Infertil. 2011;12(3):227-34.

Ago BU, Abeshi S, Njoku C, Agan TU, Ekabua J. Obstetric outcomes of booked teenage pregnancies at University of Calabar Teaching Hospital, Nigeria. Adolescent Health Med Therap. 2012:3:105–9.

Cheema HK, Bajwa BS, Kaur K, Joshi H. Prevalence and possible risk factors of anemia in different trimesters. IJCMR. 2016;3(4):1194-7.

Aabidha PM, Cherian AG, Paul E, Helan J. Maternal and fetal outcome in preeclampsia in a secondary care hospital in South India, Christian Fellowship Hospital, Oddanchatram. J Family Med Prim Care. 2015;4(2):257-60.

Simpson LL. Maternal medical disease: risk of antepartum fetal death. Sem Perinatol. 2002;26(1):42–50.

Devi BN, Varalaxmi B, Jyothirmayi T, Lahari N. Maternal outcome in pregnancy with severe anaemia: Prospective study in a tertiary care hospital in Andhra Pradesh. IOSR-JDMS. 2015;14:06-10.

Swamy MK, Kamal P, Shailaja N. Maternal and perinatal outcome during expectant management of severe pre-eclampsia between 24 and 34 wks of gestation. J Obstet Gynaecol India. 2012;62(4):413–8.

Liu S, Joseph KS, Liston RM, Bartholomew, Walker M, Leon JA, et al. Incidence, risk factors and associated complications of eclampsia. Obstet Gynaecol. 2011;118(5):987-94.

Singhal SR, Deepika, Anshu, Nanda N. Maternal and perinatal outcome in severe preeclampsia. JSAFOG. 2009;1(3):25-8.

Ndoni E, Hoxhallari R, Bimbashi A. Evaluation of Maternal Complications in Severe Preeclampsia in a University Hospital in Tirana. Macedonian J Med Sci. 2016;4(1):102-6.