Acute viral Hepatitis E in antenatal women: a multicenter prospective study


  • Kaveri Shaw Patel Department of Obstetrics and Gynecology, Shalby Multispecialty Hospitals, Jabalpur, Madhya Pradesh, India
  • Manish Tiwari Department of Gasteroenterology, Shalby Multispecialty Hospitals, Jabalpur, Madhya Pradesh, India
  • Sudha Choubey Department of Obstetrics and Gynecology Sudha Nursing Home and High-risk Pregnancy Center, Gol bazaar, Jabalpur, Madhya Pradesh, India
  • Anivesh Jain Department of Intensive Care Unit, Shalby Multispecialty Hospitals, Jabalpur, Madhya Pradesh, India
  • Lovely Jain Department of Anatomy, NSCB Medical College, Jabalpur, Madhya Pradesh, India
  • Manish Gupta Department of Pathology, Shalby Multispecialty Hospitals, Jabalpur, Madhya Pradesh, India



Acute viral hepatitis, Fulminant, Hepatitis E, Hepatic encephalopathy, Pregnancy


Background: Hepatitis E has poor prognosis in pregnancy and leads to 20-30% mortality in term cases. The Aim of the study was to observe the trend of maternal and perinatal outcome in acute viral hepatitis E.

Methods: A prospective study conducted in two high risk obstetric center of Jabalpur district in January 2015 to December 2017. The inclusion criteria were all antenatal women diagnosed with acute viral Hepatitis E entering to the Intensive care unit of any gestational age who later delivered in the same center. Other than acute hepatitis E all acute hepatitis cases and women missed in follow up in delivery were excluded from the study. The data collected on demographic, clinical and biochemical variables in excel sheet and descriptive analysis done by SPSS system.

Results: There were 72 antenatal women enrolled with mentioned criteria in study duration. Out of these only 67 were in follow up and alive till their delivery in the same set ups. Out of these 70.14% were Primigravida of median age 27 year. The mean gestational age at detection of hepatitis E was 30.3week. The maternal mortality observed was 17.9% (12/67) in the total study population. The high grade of mortality was significantly associated with high grade of disease. There were 19.4% (13/67) perinatal (mortality seen which included intrauterine (14.9%) and neonatal (4.4%).

Conclusions: The severity of Hepatitis and high grade of hepatic encephalopathy following poor primary care in the beginning of disease results in poor perinatal and maternal outcome.


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