Comparison of metformin and insulin in the treatment of gestational diabetes: a retrospective study

Neeta Bansal; Priyanka Chaudhary; Monika Ramola; Namrata Saxena

doi:10.18203/2320-1770.ijrcog20164342

Authors

Neeta Bansal Department of Obstetrics and Gynecology, Sri Guru Ram Rai institute of Medical and Health Sciences, Patel Nagar, Dehradun, India
Priyanka Chaudhary Department of Obstetrics and Gynecology, Sri Guru Ram Rai institute of Medical and Health Sciences, Patel Nagar, Dehradun, India
Monika Ramola Department of Obstetrics and Gynecology, Sri Guru Ram Rai institute of Medical and Health Sciences, Patel Nagar, Dehradun, India
Namrata Saxena Department of Obstetrics and Gynecology, Sri Guru Ram Rai institute of Medical and Health Sciences, Patel Nagar, Dehradun, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20164342

Keywords:

Gestational diabetes, Hypoglycemia, Insulin, Metformin

Abstract

Background: As various data are available on treatment of gestational diabetes mellitus (GDM), our aim is to compare the effect of treatment of metformin, insulin and diet control in GDM on maternal and neonatal outcomes.

Methods: A retrospective study was conducted and it includes 50 women of GDM treated with Metformin, 50 women with insulin and 50 with only diet control without any drug.

Results: The outcome was not much different in all groups studied. Maternal outcomes were similar in all three groups. The difference was: post prandial glucose values after 2 hour of oral glucose were slightly high in the insulin group than in the metformin group (p <0.003). Neonatal outcome was also not different in all groups. But the incidence of neonatal hypoglycemia was higher in the insulin group (p = 0.03).

Conclusions: The study suggests that metformin is effective for GDM and maternal or neonatal outcomes were similar as compared with insulin.