The study of association between maternal serum magnesium levels and preterm labour in a tertiary care hospital

Shifali Anand, Jyoti Hak, Niveditaa Prashar, Nikita Gandotra, Rohini Jaggi


Background: Serum magnesium level in pregnancy is a valuable tool to find out preterm onset of labour. In the asymptomatic group, greater surveillance and administration of steroids, tocolytics and transfer to a higher centre wherever necessary has to be done with mothers with low serum magnesium level. The objective of the study is to find association between serum magnesium levels and women with preterm labour, and to compare these values with those patients who have a term delivery.

Methods: The subjects included 100 pregnant women with preterm labour (cases) between 28 and 37 weeks gestation (Group A) and similar number of pregnant women with term labour (controls) between 37 and 40 weeks (Group B). Inclusion criteria for cases was singleton pregnancy, painful uterine contractions more than two in 30 minutes, intact fetal membranes, cervical dilatation (at least 1 cm) and effacement (80%). Serum magnesium levels were done in both the groups. Patients were followed until delivery. Routine antenatal investigations were done. Serum levels of magnesium were estimated by Erba’s semi auto-analyser.

Results: 62% patients in Group A were from rural areas. More patients in Group A (70%) were from low socioeconomic class. More women in Group A were anaemic (44%). Mean value of hemoglobin in Group A was 9.93gm/dL. More patients in Group A had muscle cramps (89%). VLBW (<1500gm) neonates were more in Group A (21%). Also, LBW (1500-2499gm) neonates were more in Group A (60%). Mean neonatal birth weight in Group A (1907.3gm) was less. Neonatal morbidity and mortality was observed significantly more in Group A. Mean serum magnesium was less in Group A. Mean serum magnesium levels in primi and multigravida patients were less in Group A. Moreover, mean serum magnesium levels were less in urban and rural patients in Group A. Mean serum magnesium levels were less in normal and overweight patients in Group A. Also, mean serum magnesium levels were less in patients with cervical dilatation <3cm and >3cm in Group A.

Conclusions: Low maternal serum magnesium level is associated with preterm labour. Patients with preterm labour have significantly low serum magnesium level when compared with labour at term.


Maternal serum magnesium, Preterm labour, Term delivery2320-1770.ijrcog20193773

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Arias F, Bhide A, Arulkumaran S, Damania K, Daftary S. Preterm parturition syndrome. Practical Guide to high risk pregnancy and delivery, 3rd Edition. Elsevier India; 2008:193-204.

Cunningham FG, Leveno KJ, Bloom SL, Spong CY, Dashe JS, Hoffman BL, et al. Preterm labour. In: Williams Obstetrics, 24th edition. McGraw-Hill Education, New York; 2014:829-861.

Hantoushzadeh S, Jafarabadi M, Khazardoust S. Serum magnesium levels, muscle cramps, and preterm labor. Inter J Gynecol Obstet. 2007;98(2):153-4.

Durlach J. New data on the importance of gestational Mg deficiency. J Am Coll Nutr. 2004;23:694-700S.

Begum AA, Das TR. Low serum magnesium level in preterm labour. J Bangladesh Coll Phys Surg. 2010;28:86-91.

Shahid AR, Hosna AU, Tahmina HZ. Hypomagnesemia in pregnancy: a predictor of preterm labour. J Dhaka Med Coll. 2010;19(1):51-7.

Bhat S, Waheed A, Chisti T, Habib H. Hypomagnesemia as a marker for preterm labour and its association with socioeconomic status. J Invest Biochem. 2012;1(1):24-30.

Mahmoud SA, Saleh IM, Khalaf HH. The correlation between maternal hypomagnesemia and preterm labour. Int J Reprod Contracept Gynaecol. 2016;5(8):2571-5.

Jenabi E, Poorolajal J, Fereidooni B, Asltoghiri M, Hejrati P. The association between maternal serum magnesium level and pregnancy outcomes. J Postgrad Med Inst. 2017;31(1):77-81.

Khani S, Shokrzadeh M, Karamoddini PK, Shahmohammadi S. The relationship between maternal serum magnesium level and preterm birth. Pak J Biol Sci. 2010;13(7):335-9.

Kumar AN. Correlation of serum magnesium level with increase in parity and comparison among rural and urban pregnant women. Int J Cur Bio Med Sci. 2012;2(1):185-7.

Manzoor S, Manzoor M, Manzoor M. Maternal anemia as a risk factor for preterm labour. Merit Res J Med Sci. 2015;10:472-5.

Shaikh K, Das CM, Baloch GH, Abbas T, Fazlani K, Jaffery MH, et al. Magnesium associated complications in pregnant women. World Appl Sci J. 2012;17(9):1074-8.

Khani S, Shokrzadeh M, Karamoddini PK, Shahmohammadi S. The relationship between maternal serum magnesium level and preterm birth. Pak J Biol Scie. 2010;13(7):335-9.

Almonte RA, Heath DL, Whitehall J, Russell MJ, Patole S, Vink R. Gestational magnesium deficiency is deleterious to fetal outcome. Biol Neonate. 1999;76:26-32.

Sharma A, Kharb S, Vineeta, Gulati N. Serum magnesium levels in preterm labour in relation to socioeconomic status. Indian J Clin Biochem. 1998;13(2):123-5.

Pathak P, Kapoor SK, Kapil U, Dwivedi SN. Serum magnesium level among pregnant women in a rural community of Haryana State, India. Eur J Clin Nutr. 2003;57:1504-06.