A study of obstetric acute renal injury
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20182527Keywords:
Acute kidney injury, Maternal mortality, Obstetric hemorrhage, SepsisAbstract
Background: Acute renal or kidney injury (AKI) is a clinical syndrome characterized by a sudden decline in glomerular filtration rate leading to decreased excretion of nitrogenous waste products. It continues to be a common problem in developing countries. The aim of this study was to understand AKI characteristics in pregnancy and identify the factors related to its unfavorable outcome.
Methods: This prospective study was conducted between January 2014 to December 2017. Out of 1057 patients delivered in our institute during this period, out of which 26 patients with Obstetric AKI were included in this study.
Results: Incidence of obstetric AKI was 2.64 %. Their age varied from 19 to 34 years, with an average of 26.2 years. About 21(80.8%) patients had not received antenatal care. The main causes of AKI were obstetric hemorrhage (38.46%) and puerperal sepsis (15.38%). The outcome was favorable with complete renal function recovery in 55.76% patients. Two (7.69 %) patients became dialysis dependent. Maternal mortality was one (3.84%).
Conclusions: Obstetric AKI is a critical situation in developing countries. Lack of antenatal care (80.8%) is a major contributing factor for obstetric-related complications leading to renal failure. Obstetric hemorrhage (38.46 %) is the most common cause of obstetric AKI. Late referral in 9 (34.61%), puerperal sepsis in three (33.33%), obstetric hemorrhage in three (33.33%) and combined sepsis and hemorrhage in two (27.77%) are the common contributing factors leading to its unfavorable outcomes as maternal morbidity and mortality. Hence, a multidisciplinary approach is warranted to prevent such an avoidable complication.
References
Jefferson A, Thurman JM, Schrier RW. Pathophysiology andetiology of acute kidney injury. In: Floege J, Johnson RJ, Feehally J, editors. Comprehensive clinical nephrology. New York:Elsevier Saunders. 2010;806-7.
Beaufils MB. Pregnancy. In: Davidson AM, Cameron JS, Grunfeld JP, et al, editors. Clinical nephrology. 3rd ed. New York: Oxford University Press. 2005;1704-28.
Prakash J, Tripathi K, Pandey LK, Gadela SR. Renal cortical necrosis in pregnancy-related acute renal failure. J Indian Med Ass. 1996;94(6):227-9.
Goplani KR, Shah PR, Gera DN, Gumber M, Dabhi M, Feroz A, et al. Pregnancy-related acute renal failure: A single-center experience. Indian J Nephrol. 2008;18(1):17.
Rani PU, Narayen G, Anuradha G. Changing trends in pregnancy related acute renal failure. J Obstet Gynecol India. 2002;52:36-8.
Khanal N, Ahmed E, Akhtar F. Factors predicting the outcome of acute renal failure in pregnancy. J Coll Physicians Surg Pak. 2010;20(9):599-603.
Pertuiset N, Grunfeld JP. Acute renal failure in pregnancy. Baillieres Clin Obstet Gynaecol. 1994;8(2):333-51.
Schrier RW. Diseases of kidney and urinary tract. Philadelphia: Lippincott Williams and Wilkins; 2001.
Ali A, Zafar S, Mehmood A, Nisar A. Obstetrical acute renal failure from frontier province: a 3 years prospective study. J Postgrad Med Inst (Peshawar-Pakistan). 2011;18(1)109-16.
Rizwan N, Uddin SN. Obstetrical acute renal failure: a challenging medical complication. J Ayub Med Coll Abbottabad. 2011;23(4):66-8.
Ansari MR, Laghari MS, Solangi KB. Acute renal failure in pregnancy: one year observational study at Liaquat University Hospital, Hyderabad. J Pak Med Assoc. 2008;58(2):61-4.
Chugh KS, Singhal PC, Sharma BK. ARF of obstetric origin. J Obstet Gynecol. 1976;108:253-61.
Kleinknecht D, Gru¨nfeld JP, Gomez PC, et al. Diagnostic procedures and long term prognosis in bilateral renal cortical necrosis. Kidney Int. 1973;4:390-400.
Khalil MA, Azhar A, Anwar N, Wali R. Aetiology, maternal and foetal outcome in 60 cases of obstetrical acute renal failure. J Ayub Med Coll. 2009;21(4):46-9.
Chaudhri N, But GU, Masroor I, Qureshi MA, Shezad MN, Abbasi MSR, et al. Spectrum and short term outcome of pregnancy related acute renal failure among women. Ann Pak Inst Med Sci. 2011;7(2):57-61.
Kumar KS, Krishna CR, Siva Kumar V. Pregnancy related acute renal failure. J Obstet Gynecol India. 2006;56(4):308-10.
Patel ML, Sachan R, Radheshyam PS. Acute renal failure in pregnancy: tertiary centre experience from north Indian population. Niger Med J. 2013;54(3):191-5.