Use of MTP kit (Mifepristone and Misoprostol combination pack) for 1st trimester MTP (up to 63 days) at GMERS Dharpur, Patan, Gujarat, India

Authors

  • Parul S. Jani Department of Obstetrics and Gynecology, GMERS Medical College, Dharpur, Patan, Gujarat, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20183763

Keywords:

Mifepristone and Misoprostol, MTP, MTP pill

Abstract

Background: MTP has been legalized in India since 1971. MTP pill (Medical abortion) refers for early pregnancy termination (usually before 9 week gestation) performed without any primary surgical interventions. This study was called out to measure its effectiveness and safety as an abortificiant drug.

Methods: This is a prospective study of 57 cases, conducted at OBSTETRIC and GYNECOLOGY Department, GMERS Medical College, Dharpur, Patan (N.G.) from April 2017 to April 2018.

Results: In present study,61.4% women are of 20-30 years of age. Majority of women are (82.5%) of 2nd and 3rd para. Complete abortion was found in 91.2%. Incomplete abortion was in 7%. And there was no effect in 1.8%. Major side effects were bleeding (84.2%), abdominal pain (85.9%). Misoprostol related side effects are minimal.

Conclusions: The present observational study demonstrates that mifepristone and misoprostol combined therapy is an effective and well tolerated medication in Indian adult women (≥18 years) requiring medical termination of intrauterine pregnancy (MTP) up to 63 days’ gestation.

References

Use of RU-486 with Misoprostol for early abortions in India. Guidelines for Medical Officers, WHO-CCR in Human Reproduction. All India Institute of Medical Sciences, Ministry of Health and Family Welfare, Government of India and India Council of Medical Research 2003.

Handbook on medical methods of abortion. Available at http://www.health.mp.gov.in/mtp/MMA Reference%20Manual.pdf

The Federation of Obstetric and Gynecological Societies of India. Available at http://www.fogsi.org/index.php?option=com_content and view=articleandid=97Itemid=16

Government of India. The medical termination of pregnancy rules (amendment). 2003. Ministry of Health and Family Welfare. Department of Family Welfare: notifi cation, New Delhi, the13thJune2003.Available at http;//mohfw,nic.in/index 1.php?sublinkid=3618andlevel=4andlid=26020andlang=1.

Cadepond F, Ulman A, Baulieu E. RU486 (mefipristone) Mechanism of action and clinical uses. Annual Rev Med. 1997;48:129-56.

Ashok PW, Flet GM and Templeton A. Mefipristone verses vaginaly administered misoprostol for cervical priming before first trimester termination of pregnancy: A ramdemised, controlled study. American Journal og obstetretics and gynecology 2000;183 (4); 998-1002.

Van der Veen N, Brouns J, Doornbos J and Van Wijngaarden W. Misoprostol and termination of pregnancy: is there a need for ultrasound screening in a general population to assess the risk for adverse outcome in cases of uterine anomaly. Arch Gynecol Obstet. 2011;283(1):1-5.

Refresher course of medial abortion services. Available at www.ipas.org.-/ media/files/Ipas%20Publications/REFMAINDE09.ASHX.

Sarojini TR, Ashakiran BT Bhanu, Radhika. Over-the-counter MTP pills and it’s impact on women’s health. J Obstet Gynecol India. 2017;67(1):37-41.

Shrivastava V. Safety, efficacy and acceptability of medical abortion with mefipristone and misoprostol in Nepalese women. Nepal J Obstet Gynecol. 2007;2 (2):54-8.

Kathleen K, Leslie M, Patricia L, Mithcell D. Mifepristone and Misoprostol for early pregnancy failure: a coholr analysis. Am J Obstet Gynecol. 2011;204(5):386.e1-6.

Schaff EA, Eisinger SH, Stadalius LS, Franks P, Gore BZ, Poppema S. Low dose mifepristone 200mg and vaginal misoprostol for abortion. Contraception. 1999 Jan 1;59(1):1-6.

Spitz IM, Bardin CW, Benton L, Robbins A. Early pregnancy termination with mifepristone and misoprostol in the United States. N Engl J Med. 1998 Apr 30;338(18):1241-7.

Kruse B, poppema S, Creinin MD, Paul M. Management of side effects and complications in medical abortion. Am J Obstet Gynecol. 2000;183(2):S65-S75.

El-Refaey H Rajasekar D, Abadalia M, Calder L, Templeton A. Induction of abortion with Mifepristone (RU 486) and oral or vaginal Misoprostol. New Engl J Medic. 2008;332:983-8.

Urquhart DR, Templeton AA, Shinewi F. The efficacy and tolerance of mifepristone and prostaglandin in termination of pregnancy of less than 63 days gestation; UK multicenter study-final results. Contraception. 1997;55:1-5.

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Published

2018-08-27

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Original Research Articles