DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20184172

Primary ovarian leiomyoma in young woman with premature ovarian failure

Vidhi Chaudhary, Kiran Aggarwal, Anita Nangia

Abstract


Authors present a rare case of primary ovarian leiomyoma in a young female with premature ovarian failure. A 39-year-old female with premature ovarian failure presented with large unilateral adnexal mass, with mildly elevated CA-125 levels, underwent staging laparotomy where the left ovarian mass along with tubes was removed. Contralateral ovary and uterus were preserved.  Final diagnosis was Primary ovarian leiomyoma on histopathology and immunohistochemical analysis. Preoperative diagnosis is difficult with solid ovarian tumors. In presence of mildly elevated CA-125 and negative tumor markers, ovarian leiomyoma must be considered as a differential diagnosis and conservative surgery be planned as these patients are desirous of future fertility options. Definitive diagnosis is confirmed by histopathology and immunohistochemical analysis.


Keywords


Ovarian leiomyoma, Ovarian tumors, Premature ovarian failure

Full Text:

PDF

References


Taskin MI, Ozturk E, Yildirim F, Ozdemir N, Inceboz U. Primary ovarian leiomyoma: a case report. Int J Surg Case Rep. 2014;5:665-8.

Agrawal R, Kumar M, Agrawal L, Agrawal KK. A huge primary ovarian leiomyoma with degenerative changes: an unusual. J Clin Diagn Res. 2013;7(6):1152-4.

Blue NR, Felix JC, Jaque J. Primary ovarian leiomyoma in a premenarchal adolescent: first reported case. J Pediatr Adolesc Gynecol. 2014;27:e87-88.

Lim S, Jeon H. Bilateral primary ovarian leiomyoma in a young woman: case report and literature review. Gynecol Oncol. 2004;95:733-5.

Tomas D, Lenicek T, Tuckar N, Puljiz Z, Ledinsky M, Kruslin B. Primary ovarian leiomyoma associated with endometriotic cyst presenting with symptoms of acute appendicitis: a case report. Diagn Pathol. 2009;4:25.

Khaffaf N, Khaffaf H, Wuketich S. Giant ovarian leiomyoma as a rare cause of acute abdomen and hydronephrosis. Obstet Gynecol. 1996;87:872-3.

Güney M, Ozsoy M, Oral B, Mungan T, Kapucuoğlu N. Unilateral primary ovarian leiomyoma in adolescent: a case report. Arch Gynecol Obstet. 2007;275:507-10.

Yasushi K, Noriyuki T, Masako S, Kaei N, Isao M. Magnetic resonance imaging findings in leiomyoma of the ovary: a case report. Arch Gynecol Obstet. 2005;273:298-300.

Koo YJ, Cho YJ, Kim JY, Lee JE, Kim ML, Kim JM, et al. Ovarian leiomyoma as a potential cause of compromised fertility. Fertil Steril. 2011;95:1120.e11-4.

Doss BJ, Wanek SM, Jacques SM, Qureshi F, Ramirez NC, Lawrence WD. Ovarian leiomyomas: clinicopathologic features in fifteen cases. Int J Gynecol Pathol. 1999;18:63-8.

Mallick D, Saha M, Chakrabarti S, Chakraborty J. Leiomyoma of broad ligament mimicking ovarian malignancy- report of a unique case. Kathmandu Univ Med J (KUMJ). 2014;12(47):219-21.

Wei C, Lilic N, Shorter N, Garrow E. Primary ovarian leiomyoma: a rare cause of ovarian tumor in adolescence. J Pediatr Adolesc Gynecol. 2008;21(1):33-6.

Plewka A, Plewka D, Madej P, Nowaczyk G, Sieron-Stoltny K, Jakubiec-Bartnik B. Processes of apoptosis and cell proliferation in uterine myomas originating from reproductive and perimenopausal women. Folia Histochem Cytobiol. 2011;49:398-404.

Costa MJ, Morris R, DeRose PB, Cohen C. Histologic and immunohistochemical evidence for considering ovarian myxoma as a variant of the thecoma-fibroma group of ovarian stromal tumors. Arch Pathol Lab Med. 1993;117:802-8.